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Science Forum Index » Life Extension Forum » simvastatin promotes BMP-2, inhibits adipocytic differentiat
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| kofi |
 Posted: Sat Jan 03, 2004 1:02 am |
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Biochem Biophys Res Commun. 2003 Aug 29;308(3):458-62. Related Articles,
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Simvastatin induces osteoblastic differentiation and inhibits
adipocytic differentiation in mouse bone marrow stromal cells.
Song C, Guo Z, Ma Q, Chen Z, Liu Z, Jia H, Dang G.
Department of Orthopedics, Peking University Third Hospital,
Beijing, PR China.
To clarify the mechanism of the stimulatory effect of statins on
bone formation, we investigated the effect of simvastatin, a widely used
statin, on osteoblastic and adipocytic differentiation in primary
cultured mouse bone marrow stromal cells (BMSCs). Simvastatin treatment
enhanced the expression level of mRNA for osteocalcin and protein for
osteocalcin and osteopontin, and increased alkaline phosphatase activity
significantly (p<0.05). After BMSCs were exposed to an adipocyte
differentiation agonist, Oil Red O staining, fluorescence activated cell
sorting, and decreased expression level of lipoprotein lipase mRNA
showed that treatment with simvastatin significantly inhibits adipocytic
differentiation compared to controls that did not receive simvastatin
(p<0.05). Lastly, we found that simvastatin induces high expression of
BMP(2) in BMSCs. These observations suggested that simvastatin acts on
BMSCs to enhance osteoblastic differentiation and inhibits adipocytic
differentiation; this effect is at least partially mediated by inducing
BMP(2) expression in BMSCs.
PMID: 12914771 [PubMed - indexed for MEDLINE] |
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