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Science Forum Index » Life Extension Forum » Testosterone, insulin, SHBG levels and inflammation
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| kofi |
 Posted: Wed Dec 31, 2003 12:31 am |
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Guest
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Well, low SHBG is associated with higher inflammation (insulin, glucose
and C-reactive protein). That makes sense. Low SHBG, however, is also
associated with low testosterone. I would have expected just the
opposite. It may be a cholesterol thing. (I wonder if low T levels
resulted in higher levels of DHT, which binds to the androgen receptor
with much greater affinity. Too bad they didn't measure this.)
Could somebody tell me what's going on with the iron stores here. I
don't pay much attention to that part of metabolism.
Eur J Endocrinol. 2003 Dec;149(6):601-8. Related Articles, Links
Click here to read
Sex hormones, inflammation and the metabolic syndrome: a
population-based study.
Laaksonen DE, Niskanen L, Punnonen K, Nyyssonen K, Tuomainen TP,
Salonen R, Rauramaa R, Salonen JT.
Department of Medicine, Kuopio University Hospital, Kuopio, Finland.
OBJECTIVE: Mild hypoandrogenism in men is associated with features
of the metabolic syndrome, but the association with the metabolic
syndrome itself using an accepted definition has not been described.
DESIGN: Men with the metabolic syndrome were identified and testosterone
and sex hormone-binding globulin (SHBG) levels were determined in a
population-based cohort of 1896 non-diabetic middle-aged Finnish men.
RESULTS: Calculated free testosterone and SHBG were 11% and 18% lower
(P<0.001) in men with the metabolic syndrome (n=345, World Health
Organisation definition). After categorisation by tertiles and adjusting
for age and body mass index, total and free testosterone and SHBG were
inversely associated with concentrations of insulin, glucose,
triglycerides, C-reactive protein (CRP) and CRP-adjusted ferritin and
positively associated with high-density lipoprotein cholesterol. Men
with free testosterone levels in the lowest third were 2.7 (95%
confidence interval (CI) 2.0-3.7) times more likely to have the
metabolic syndrome in age-adjusted analyses, and 1.7 (95% CI 1.2-2.4)
times more likely even after further adjusting for body mass index.
Exclusion of men with cardiovascular disease did not alter the
association. The inverse association of SHBG with the metabolic syndrome
was somewhat stronger. CONCLUSIONS: Low testosterone and SHBG levels
were strongly associated not only with components of the metabolic
syndrome, but also with the metabolic syndrome itself, independently of
body mass index. Furthermore, sex hormones were associated with
inflammation and body iron stores. Even in the absence of late-stage
consequences such as diabetes and cardiovascular disease, subtle
derangements in sex hormones are present in the metabolic syndrome, and
may contribute to its pathogenesis.
PMID: 14641004 [PubMed - in process] |
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