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Leptin is found expressed in hair follicles and is part of the body's
stress axis.
Acta Diabetol. 2003 Oct;40 Suppl 1:S101-5. Related Articles, Links
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Relationship of leptin and sex hormones to bone mineral density in
men.
Sun AJ, Jing T, Heymsfield SB, Phillips GB.
Obesity Research Center, St Luke's-Roosevelt Hospital Center,
Department of Medicine and Institute of Human Nutrition, College of
Physicians and Surgeons, Columbia University, New York, USA.
Sex hormones are strongly associated with bone mineral density (BMD)
in adult humans. Leptin, a hormonal product of the OB gene, also appears
to be associated with BMD, but results from previous studies are
conflicting. Most of the studies in this area have been in women and
apparently none have simultaneously analyzed the relationship of
estradiol, testosterone, and leptin with BMD in healthy men. To address
these issues, serum sex hormones, sex-hormone-binding globulin (SHBG),
leptin, dehydroepiandrosterone sulfate (DHEAS), and insulin were
measured in 50 apparently healthy men, 18-66 years of age. After
controlling for age and body mass index (BMI), BMD correlated positively
with estradiol ( p=0.007) and testosterone ( p=0.019), but negatively
with leptin ( p=0.001). No significant correlations between BMD and
SHBG, DHEAS, or insulin were observed. In multiple regression analysis
with age, BMI, estradiol, testosterone, and leptin as the independent
variables, only age ( p<0.05), BMI ( p<0.001), and leptin ( p=0.004)
were significantly related to BMD. These findings suggest that in men,
leptin may have an important negative relationship with BMD.
PMID: 14618446 [PubMed - in process] |
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