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Science Forum Index » Life Extension Forum » Effects of sage on cognition and recall
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| kofi |
 Posted: Thu Jan 01, 2004 12:10 am |
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Pharmacol Biochem Behav. 2003 Jun;75(3):669-74. Related Articles, Links
Click here to read
Salvia lavandulaefolia (Spanish Sage) enhances memory in healthy
young volunteers.
Tildesley NT, Kennedy DO, Perry EK, Ballard CG, Savelev S, Wesnes
KA, Scholey AB.
Human Cognitive Neuroscience Unit, Division of Psychology,
Northumbria University, Newcastle upon Tyne NE1 8ST, UK.
Sage (Salvia) has a longstanding reputation in British herbal
encyclopaedias as an agent that enhances memory, although there is
little evidence regarding the efficacy of sage from systematized trials.
Based on known pharmacokinetic and binding properties, it was
hypothesised that acute administration of sage would enhance memory in
young adult volunteers. Two experiments utilised a placebo-controlled,
double-blind, balanced, crossover methodology. In Trial 1, 20
participants received 50, 100 and 150 microl of a standardised essential
oil extract of Salvia lavandulaefolia and placebo. In Trial 2, 24
participants received 25 and 50 microl of a standardised essential oil
extract of S. lavandulaefolia and placebo. Doses were separated by a
7-day washout period with treatment order determined by Latin squares.
Assessment was undertaken using the Cognitive Drug Research computerised
test battery prior to treatment and 1, 2.5, 4 and 6 h thereafter. The
primary outcome measures were immediate and delayed word recall.The 50
microl dose of Salvia essential oil significantly improved immediate
word recall in both studies. These results represent the first
systematic evidence that Salvia is capable of acute modulation of
cognition in healthy young adults.
PMID: 12895685 [PubMed - in process] |
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