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Science Forum Index » Medicine - Nursing Forum » Retinitis Pigmentosa and Oxidative Stress...
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| ironjustice... |
 Posted: Thu Jul 24, 2008 5:42 am |
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Guest
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Blockade of neuronal nitric oxide synthase reduces cone cell death in
a model of retinitis pigmentosa.
Komeima K, Usui S, Shen JK, Rogers BS, Campochiaro PA
Free Radic Biol Med 2008 Jun 28.
Retinitis pigmentosa (RP) is a group of diseases in which many
different mutations cause rod photoreceptor cells to die and then
gradually cone photoreceptors die due to progressive oxidative
damage.
In this study, we have shown that peroxynitrite-induced nitrosative
damage also occurs.
In the rd1 mouse model of RP, there was increased staining for S-
nitrosocysteine and nitrotyrosine protein adducts that are generated
by peroxynitrite.
Peroxynitrite is generated from nitric oxide (NO) and superoxide
radicals.
After degeneration of rods, injection of hydroethidine resulted in
strong fluorescence in the retina of rd1 mice, indicating high levels
of superoxide radicals, and this was reduced, as was nitrotyrosine
staining, by apocynin, suggesting that overaction of NADP(H) oxidase
is at least partially responsible.
Treatment of rd1 mice with a mixture of nitric oxide synthase (NOS)
inhibitors markedly reduced S-nitrosocysteine and nitrotyrosine
staining and significantly increased cone survival, indicating that NO-
derived peroxynitrite contributes to cone cell death.
Treatment with 7-nitroindazole, a relatively specific inhibitor of
neuronal NOS, also significantly reduced cone cell death, but
aminoguanidine, a relatively specific inhibitor of inducible NOS, did
not.
These data suggest that NO generated by neuronal NOS exacerbates
oxidative damage to cones in RP and that combined therapy to reduce NO
and oxidative stress should be considered.
Free radical biology & medicine [Free Radic Biol Med]
--------------------------------------------------------------------------------
Who loves ya.
Tom
Jesus Was A Vegetarian!
http://tinyurl.com/2r2nkh
Man Is A Herbivore!
http://tinyurl.com/4rq595
DEAD PEOPLE WALKING
http://tinyurl.com/zk9fk |
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| Posted: Thu Jul 24, 2008 7:17 am |
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Guest
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Another purely genetic disorder. If you have the genes for it you will
get it. If you have the gene for blue eyes you will have them.
Jesus ate a mediterranean diet. |
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| ironjustice... |
| Posted: Thu Jul 24, 2008 11:43 am |
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Guest
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"Therapy to reduce oxidative stress should be considered."
-----
Blockade of neuronal nitric oxide synthase reduces cone cell death in
a model of retinitis pigmentosa.
Komeima K, Usui S, Shen JK, Rogers BS, Campochiaro PA
Free Radic Biol Med 2008 Jun 28.
Retinitis pigmentosa (RP) is a group of diseases in which many
different mutations cause rod photoreceptor cells to die and then
gradually cone photoreceptors die due to progressive oxidative
damage.
In this study, we have shown that peroxynitrite-induced nitrosative
damage also occurs.
In the rd1 mouse model of RP, there was increased staining for S-
nitrosocysteine and nitrotyrosine protein adducts that are generated
by peroxynitrite.
Peroxynitrite is generated from nitric oxide (NO) and superoxide
radicals.
After degeneration of rods, injection of hydroethidine resulted in
strong fluorescence in the retina of rd1 mice, indicating high levels
of superoxide radicals, and this was reduced, as was nitrotyrosine
staining, by apocynin, suggesting that overaction of NADP(H) oxidase
is at least partially responsible.
Treatment of rd1 mice with a mixture of nitric oxide synthase (NOS)
inhibitors markedly reduced S-nitrosocysteine and nitrotyrosine
staining and significantly increased cone survival, indicating that
NO-
derived peroxynitrite contributes to cone cell death.
Treatment with 7-nitroindazole, a relatively specific inhibitor of
neuronal NOS, also significantly reduced cone cell death, but
aminoguanidine, a relatively specific inhibitor of inducible NOS, did
not.
These data suggest that NO generated by neuronal NOS exacerbates
oxidative damage to cones in RP and that combined therapy to reduce
NO
and oxidative stress should be considered.
Free radical biology & medicine [Free Radic Biol Med]
--------------------------------------------------------------------------------
Who loves ya.
Tom
Jesus Was A Vegetarian!
http://tinyurl.com/2r2nkh
Man Is A Herbivore!
http://tinyurl.com/4rq595
DEAD PEOPLE WALKING
http://tinyurl.com/zk9fk |
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| ... |
| Posted: Thu Jul 24, 2008 1:44 pm |
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Guest
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""Therapy to reduce oxidative stress should be considered.""
What therapy for blue eyes?
This disorder is entirely a genetic one . It is not caused by what one
eats or does not eat. It is a "X" related genetic disorder.
Jesus ate a mediterranean diet. |
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| ironjustice... |
| Posted: Thu Jul 24, 2008 3:22 pm |
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Guest
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"Therapy to reduce oxidative stress should be considered."
-----
Blockade of neuronal nitric oxide synthase reduces cone cell death in
a model of retinitis pigmentosa.
Komeima K, Usui S, Shen JK, Rogers BS, Campochiaro PA
Free Radic Biol Med 2008 Jun 28.
Retinitis pigmentosa (RP) is a group of diseases in which many
different mutations cause rod photoreceptor cells to die and then
gradually cone photoreceptors die due to progressive oxidative
damage.
In this study, we have shown that peroxynitrite-induced nitrosative
damage also occurs.
In the rd1 mouse model of RP, there was increased staining for S-
nitrosocysteine and nitrotyrosine protein adducts that are generated
by peroxynitrite.
Peroxynitrite is generated from nitric oxide (NO) and superoxide
radicals.
After degeneration of rods, injection of hydroethidine resulted in
strong fluorescence in the retina of rd1 mice, indicating high levels
of superoxide radicals, and this was reduced, as was nitrotyrosine
staining, by apocynin, suggesting that overaction of NADP(H) oxidase
is at least partially responsible.
Treatment of rd1 mice with a mixture of nitric oxide synthase (NOS)
inhibitors markedly reduced S-nitrosocysteine and nitrotyrosine
staining and significantly increased cone survival, indicating that
NO-
derived peroxynitrite contributes to cone cell death.
Treatment with 7-nitroindazole, a relatively specific inhibitor of
neuronal NOS, also significantly reduced cone cell death, but
aminoguanidine, a relatively specific inhibitor of inducible NOS, did
not.
These data suggest that NO generated by neuronal NOS exacerbates
oxidative damage to cones in RP and that combined therapy to reduce
NO
and oxidative stress should be considered.
Free radical biology & medicine [Free Radic Biol Med]
--------------------------------------------------------------------------------
Who loves ya.
Tom
Jesus Was A Vegetarian!
http://tinyurl.com/2r2nkh
Man Is A Herbivore!
http://tinyurl.com/4rq595
DEAD PEOPLE WALKING
http://tinyurl.com/zk9fk |
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| Back to top |
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| ... |
| Posted: Fri Jul 25, 2008 2:40 am |
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Guest
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""Therapy to reduce oxidative stress should be considered.""
What therapy for blue eyes?
This disorder is entirely a genetic one . It is not caused by what one
eats or does not eat. It is a "X" related genetic disorder.
Jesus ate a mediterranean diet. |
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| Back to top |
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| ironjustice... |
| Posted: Fri Jul 25, 2008 2:50 am |
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Guest
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"Therapy to reduce oxidative stress should be considered."
-----
Blockade of neuronal nitric oxide synthase reduces cone cell death in
a model of retinitis pigmentosa.
Komeima K, Usui S, Shen JK, Rogers BS, Campochiaro PA
Free Radic Biol Med 2008 Jun 28.
Retinitis pigmentosa (RP) is a group of diseases in which many
different mutations cause rod photoreceptor cells to die and then
gradually cone photoreceptors die due to progressive oxidative
damage.
In this study, we have shown that peroxynitrite-induced nitrosative
damage also occurs.
In the rd1 mouse model of RP, there was increased staining for S-
nitrosocysteine and nitrotyrosine protein adducts that are generated
by peroxynitrite.
Peroxynitrite is generated from nitric oxide (NO) and superoxide
radicals.
After degeneration of rods, injection of hydroethidine resulted in
strong fluorescence in the retina of rd1 mice, indicating high levels
of superoxide radicals, and this was reduced, as was nitrotyrosine
staining, by apocynin, suggesting that overaction of NADP(H) oxidase
is at least partially responsible.
Treatment of rd1 mice with a mixture of nitric oxide synthase (NOS)
inhibitors markedly reduced S-nitrosocysteine and nitrotyrosine
staining and significantly increased cone survival, indicating that
NO-
derived peroxynitrite contributes to cone cell death.
Treatment with 7-nitroindazole, a relatively specific inhibitor of
neuronal NOS, also significantly reduced cone cell death, but
aminoguanidine, a relatively specific inhibitor of inducible NOS, did
not.
These data suggest that NO generated by neuronal NOS exacerbates
oxidative damage to cones in RP and that combined therapy to reduce
NO
and oxidative stress should be considered.
Free radical biology & medicine [Free Radic Biol Med]
--------------------------------------------------------------------------------
Who loves ya.
Tom
Jesus Was A Vegetarian!
http://tinyurl.com/2r2nkh
Man Is A Herbivore!
http://tinyurl.com/4rq595
DEAD PEOPLE WALKING
http://tinyurl.com/zk9fk |
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| Back to top |
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| ... |
| Posted: Fri Jul 25, 2008 3:31 am |
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Guest
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""Therapy to reduce oxidative stress should be considered.""
What therapy for blue eyes?
This disorder is entirely a genetic one . It is not caused by what one
eats or does not eat. It is a "X" related genetic disorder.
Jesus ate a mediterranean diet.
/ |
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| ironjustice... |
| Posted: Fri Jul 25, 2008 3:50 am |
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Guest
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| ironjustice... |
| Posted: Fri Jul 25, 2008 3:51 am |
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Guest
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"Therapy to reduce oxidative stress should be considered."
-----
Blockade of neuronal nitric oxide synthase reduces cone cell death in
a model of retinitis pigmentosa.
Komeima K, Usui S, Shen JK, Rogers BS, Campochiaro PA
Free Radic Biol Med 2008 Jun 28.
Retinitis pigmentosa (RP) is a group of diseases in which many
different mutations cause rod photoreceptor cells to die and then
gradually cone photoreceptors die due to progressive oxidative
damage.
In this study, we have shown that peroxynitrite-induced nitrosative
damage also occurs.
In the rd1 mouse model of RP, there was increased staining for S-
nitrosocysteine and nitrotyrosine protein adducts that are generated
by peroxynitrite.
Peroxynitrite is generated from nitric oxide (NO) and superoxide
radicals.
After degeneration of rods, injection of hydroethidine resulted in
strong fluorescence in the retina of rd1 mice, indicating high levels
of superoxide radicals, and this was reduced, as was nitrotyrosine
staining, by apocynin, suggesting that overaction of NADP(H) oxidase
is at least partially responsible.
Treatment of rd1 mice with a mixture of nitric oxide synthase (NOS)
inhibitors markedly reduced S-nitrosocysteine and nitrotyrosine
staining and significantly increased cone survival, indicating that
NO-
derived peroxynitrite contributes to cone cell death.
Treatment with 7-nitroindazole, a relatively specific inhibitor of
neuronal NOS, also significantly reduced cone cell death, but
aminoguanidine, a relatively specific inhibitor of inducible NOS, did
not.
These data suggest that NO generated by neuronal NOS exacerbates
oxidative damage to cones in RP and that combined therapy to reduce
NO
and oxidative stress should be considered.
Free radical biology & medicine [Free Radic Biol Med]
--------------------------------------------------------------------------------
Who loves ya.
Tom
Jesus Was A Vegetarian!
http://tinyurl.com/2r2nkh
Man Is A Herbivore!
http://tinyurl.com/4rq595
DEAD PEOPLE WALKING
http://tinyurl.com/zk9fk |
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| Back to top |
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| ... |
| Posted: Fri Jul 25, 2008 4:12 am |
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Guest
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""Therapy to reduce oxidative stress should be considered.""
What therapy for blue eyes?
This disorder is entirely a genetic one . It is not caused by what one
eats or does not eat. It is a "X" related genetic disorder.
Jesus ate a mediterranean diet. |
|
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| Back to top |
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| ... |
| Posted: Fri Jul 25, 2008 4:14 am |
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Guest
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Regarding RP:
What exactly do you have to lose from the truth?
""Therapy to reduce oxidative stress should be considered.""
What therapy for blue eyes?
This disorder is entirely a genetic one . It is not caused by what one
eats or does not eat. It is a "X" related genetic disorder.
Jesus ate a mediterranean diet. |
|
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| Back to top |
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| ironjustice... |
| Posted: Fri Jul 25, 2008 4:25 am |
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Guest
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On Jul 25, 7:14 am, ferr... at (no spam) ironcity.com wrote:What exactly do you
have to lose from the truth? <<
Yeah ..buddy .. what DO you have to lose .. ?
""Therapy to reduce oxidative stress should be considered."
It .. obviously .. says .. ""Therapy to reduce oxidative stress should
be considered."
You seem to be having a hard time **understanding** that ..
How come .. ?
Stupidity .. ?
What ..
Explain it ..
Explain how you think these researchers didn't find .. and report ..
to those that are interested .. that .. ""Therapy to reduce oxidative
stress should be considered."
Your .. "blue eyes" is your .. "jeez I don't understand how that could
be" .. is that right .. ?
Are you asking ME .. a question .. ?
What question are you asking .. ?
I can't seem to understand what you are asking ..
You should be more .. succinct ..
If you are looking for their email addresses you may find them if you
look very hard ..
Otherwise .. buddy .. personally .. ? .. I don't really give a fk HOW
they discovered the NEED for antioxidants ..
You understand .. ?
I ain't .. interested .. in HOW or why they discovered the NEED for
antioxidant .. therapy.
YOU got a .. problem WITH .. me .. not giving a fk .. ?
Do ya .. ?
Heh .. heh ..
Who loves ya.
Tom
Jesus Was A Vegetarian!
http://tinyurl.com/2r2nkh
Man Is A Herbivore!
http://tinyurl.com/4rq595
DEAD PEOPLE WALKING
http://tinyurl.com/zk9fk
Quote: Regarding RP:
What exactly do you have to lose from the truth?
""Therapy to reduce oxidative stress should be considered.""
What therapy for blue eyes?
This disorder is entirely a genetic one . It is not caused by what one
eats or does not eat. It is a "X" related genetic disorder.
Jesus ate a mediterranean diet. |
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| Back to top |
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| ... |
| Posted: Fri Jul 25, 2008 11:19 am |
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Guest
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Are we seeing first hand the results of "rust" in the brain or the
cognitive problems of low iron?
Regarding RP:
What exactly do you have to lose from the truth?
""Therapy to reduce oxidative stress should be considered.""
What therapy for blue eyes?
This disorder is entirely a genetic one . It is not caused by what one
eats or does not eat. It is a "X" related genetic disorder.
Jesus ate a mediterranean diet. |
|
|
| Back to top |
|
| ironjustice... |
| Posted: Fri Jul 25, 2008 11:27 am |
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Guest
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On Jul 25, 2:19 pm, ferr... at (no spam) ironcity.com wrote:
Are we seeing first hand the results of "rust" in the brain or the
cognitive problems of low iron? <<
You got something to say you little .. pussy .. ?
Do ya .. ?
How come you can't just step up .. eh ..
How come ..
Have you ever wondered that .. ?
Heh .. heh ..
You little pussy ..
Retinitis and cognitive problems .. ?
No mention of that ..
Eye is pretty close to the brain .. so yes .. it could be the rust ..
or oxidative stress as the more learned of us .. speak.
Is it oxidative stress you are thinking about .. ?
Let's see with your retention skills .. ?
It is probably cognition you are talking about ..
No .. the article didn't say there was cognition problems it said
it .. what .. ?
Antioxidant therapy for people who are .. blind ..
Isn't that .. right .. mr .. medical .. guy ..
You guys really make me want to .. go to the ICU ..
Heh .. heh ..
I wonder if that is why you guys get acosted sooo .. much .. you write
articles about it .. eh .. ya little limpwristed .. pussy . .
Who loves ya.
Tom
Jesus Was A Vegetarian!
http://tinyurl.com/2r2nkh
Man Is A Herbivore!
http://tinyurl.com/4rq595
DEAD PEOPLE WALKING
http://tinyurl.com/zk9fk
Quote:
Regarding RP:
What exactly do you have to lose from the truth?
""Therapy to reduce oxidative stress should be considered.""
What therapy for blue eyes?
This disorder is entirely a genetic one . It is not caused by what one
eats or does not eat. It is a "X" related genetic disorder.
Jesus ate a mediterranean diet. |
|
|
| Back to top |
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| |
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