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Science Forum Index » Life Extension Forum » Coffee and mortality...
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 Posted: Wed Jun 11, 2008 9:57 am |
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All the studies I've ever seen link coffee consumption to decreased
mortality.
Int J Cancer. 2007 Sep 15;121(6):1312-8. Links
Coffee consumption and risk of colorectal cancer in a population-based
prospective cohort of Japanese men and women.Lee KJ, Inoue M, Otani T,
Iwasaki M, Sasazuki S, Tsugane S; JPHC Study Group.
Epidemiology and Prevention Division, Research Center for Cancer
Prevention and Screening, National Cancer Center, Tokyo, Japan.
We prospectively examined the association between coffee consumption
and the risk of developing colorectal cancer in a large population-
based cohort study (the JPHC Study) of Japanese men and women. Data
were analyzed from a population-based cohort of 96,162 subjects
(46,023 men and 50,139 women). A total of 1,163 incident colorectal
cancers were identified during the follow-up period, including 763
cases of colon cancer and 400 of rectal cancer. We observed a
significant inverse association between coffee consumption and the
risk of developing invasive colon cancer among women. Compared with
those who almost never consumed coffee, women who regularly consumed 3
or more cups of coffee per day had a RR of 0.44 (95% CI = 0.19-1.04; p
for trend = 0.04) after adjustment for potential confounding factors.
However, no significant association was found for rectal cancer in
women. In men, no significant decrease was observed in any colorectal
cancer site. Further, additional analyses on the association of green
tea consumption with colorectal cancer risk found no significant
association in men or women. These findings suggest that coffee
consumption may lower the risk of colon cancer among Japanese women.
(c) 2007 Wiley-Liss, Inc.
PMID: 17450527 [PubMed - indexed for MEDLINE] |
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| Posted: Wed Jun 11, 2008 10:00 am |
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reduced risk was apparent among men who drank at least three cups of
coffee per day compared with those who did not drink any or only
rarely drank coffee
Eur J Cancer Prev. 2007 Dec;16(6):542-8. Links
Green tea and coffee intake and risk of pancreatic cancer in a large-
scale, population-based cohort study in Japan (JPHC study).Luo J,
Inoue M, Iwasaki M, Sasazuki S, Otani T, Ye W, Tsugane S; JPHC Study
Group.
Epidemiology and Prevention Division, Research Center for Cancer
Prevention and Screening, National Cancer Center, Tokyo, Japan.
Pancreatic cancer is one of the most aggressive and treatment-
refractory malignancies in humans. The most effective means of
reducing pancreatic cancer mortality may be primary prevention.
Although laboratory studies have demonstrated that green tea possesses
anticancer activities, results from epidemiological studies have
failed to show a consistent cancer-preventive effect. In addition,
there is a lingering concern that coffee mighty increase the risk of
pancreatic cancer although the most recent epidemiological studies
showed no overall association between coffee and risk. Here, we
examined the association between the drinking of green tea or coffee
and the risk of pancreatic cancer in a large population-based cohort
study in Japan (JPHC study). In total, 102 137 participants were
followed for an average of 11 years through to the end of 2003. A
total of 233 incident cases of pancreatic cancer were identified among
1 116 945 person-years of follow-up. Overall, the risk of pancreatic
cancer was not associated with either green tea or coffee intake in
our population, although a reduced risk was apparent among men who
drank at least three cups of coffee per day compared with those who
did not drink any or only rarely drank coffee. In conclusion, our
findings support the idea that green tea or coffee consumption does
not have a substantial impact on pancreatic cancer risk in general.
PMID: 18090127 [PubMed - indexed for MEDLINE] |
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| Posted: Wed Jun 11, 2008 10:05 am |
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Moderate caffeine consumption appeared beneficial in reducing risk of
death.
Prev Med. 2007 Apr;44(4):305-10. Epub 2006 Dec 29. Links
Non-alcoholic beverage and caffeine consumption and mortality: the
Leisure World Cohort Study.Paganini-Hill A, Kawas CH, Corrada MM.
Department of Preventive Medicine, Keck School of Medicine of the
University of Southern California, CA, USA. annliahi at (no spam) usc.edu
OBJECTIVE: To examine the effects of non-alcoholic beverage and
caffeine consumption on all-cause mortality in older adults. METHODS:
The Leisure World Cohort Study is a prospective study of residents of
a California retirement community. A baseline postal health survey
included details on coffee, tea, milk, soft drink, and chocolate
consumption. Participants were followed for 23 years (1981-2004). Risk
ratios (RRs) of death were calculated using Cox regression for 8644
women and 4980 men (median age at entry, 74 years) and adjusted for
age, gender, and multiple potential confounders. RESULTS: Caffeine
consumption exhibited a U-shaped mortality curve. Moderate caffeine
consumers had a significantly reduced risk of death (multivariable-
adjusted RR=0.94, 95% CI: 0.89, 0.99 for 100-199 mg/day and RR=0.90,
95% CI: 0.85, 0.94 for 200-399 mg/day compared with those consuming
<50 mg/day). Individuals who drank more than 1 can/week of
artificially sweetened (but not sugar-sweetened) soft drink (cola and
other) had an 8% increased risk (95% CI: 1.01-1.16). Neither milk nor
tea had a significant effect on mortality after multivariable
adjustment. CONCLUSIONS: Moderate caffeine consumption appeared
beneficial in reducing risk of death. Attenuation in the observed
associations between mortality and intake of tea and milk with
adjustment for potential confounders suggests that such consumption
identifies those with other mortality-associated lifestyle and health
risks. The increased death risk with consumption of artificially
sweetened, but not sugar-sweetened, soft drinks suggests an effect of
the sweetener rather than other components of the soft drinks,
although residual confounding remains a possibility.
PMID: 17275898 [PubMed - indexed for MEDLINE]
PMCID: PMC2034362 |
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| Posted: Wed Jun 11, 2008 10:07 am |
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Diabetologia. 2006 Nov;49(11):2618-26. Epub 2006 Sep 21. Links
Coffee consumption and risk of total and cardiovascular mortality
among patients with type 2 diabetes.Bidel S, Hu G, Qiao Q, Jousilahti
P, Antikainen R, Tuomilehto J.
Diabetes and Genetic Epidemiology Unit, Department of Health Promotion
and Chronic Disease Prevention, National Public Health Institute,
Mannerheimintie 166, FIN-00300 Helsinki, Finland. siamak.bidel at (no spam) ktl.fi
AIMS/HYPOTHESIS: Higher habitual coffee drinking has been associated
with a lower risk of developing type 2 diabetes. The relation between
coffee consumption and risk of cardiovascular disease (CVD) has been
examined in many studies, but the issue remains controversial. This
study was designed to assess the association between coffee
consumption and CVD mortality among patients with type 2 diabetes.
METHODS: We prospectively followed 3,837 randomly ascertained Finnish
patients with type 2 diabetes aged 25 to 74 years. Coffee consumption
and other study parameters were determined at baseline. The
International Classification of Diseases was used to identify CHD, CVD
and stroke cases using computerised record linkage to the national
Death Registry. The associations between coffee consumption at
baseline and risk of total, CVD, CHD, and stroke mortality were
analysed by using Cox proportional hazards models. RESULTS: During the
average follow-up of 20.8 years, 1,471 deaths were recorded, of which
909 were coded as CVD, 598 as CHD and 210 as stroke. The respective
multivariate-adjusted hazard ratios in participants who drank 0-2,
3-4, 5-6, and > or =7 cups of coffee daily were 1.00, 0.77, 0.68 and
0.70 for total mortality (P<0.001 for trend), 1.00, 0.79, 0.70 and
0.71 for CVD mortality (P=0.006 for trend), 1.00, 0.78, 0.70 and 0.63
for CHD mortality (p=0.01 for trend), and 1.00, 0.77, 0.64 and 0.90
for stroke mortality (p=0.12 for trend). CONCLUSIONS/INTERPRETATION:
In this large prospective study we found that in type 2 diabetic
patients coffee drinking is associated with reduced total, CVD and CHD
mortality.
PMID: 17019600 [PubMed - indexed for MEDLINE] |
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| Posted: Wed Jun 11, 2008 10:08 am |
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Am J Clin Nutr. 2006 May;83(5):1039-46. Links
Consumption of coffee is associated with reduced risk of death
attributed to inflammatory and cardiovascular diseases in the Iowa
Women's Health Study.Andersen LF, Jacobs DR Jr, Carlsen MH, Blomhoff
R.
Department of Nutrition, Institute of Basic Medical Sciences,
University of Oslo, Oslo, Norway.
BACKGROUND: Coffee is the major source of dietary antioxidants. The
association between coffee consumption and risk of death from diseases
associated with inflammatory or oxidative stress has not been studied.
OBJECTIVE: We studied the relation of coffee drinking with total
mortality and mortality attributed to cardiovascular disease, cancer,
and other diseases with a major inflammatory component. DESIGN: A
total of 41,836 postmenopausal women aged 55-69 y at baseline were
followed for 15 y. After exclusions for cardiovascular disease,
cancer, diabetes, colitis, and liver cirrhosis at baseline, 27,312
participants remained, resulting in 410,235 person-years of follow-up
and 4265 deaths. The major outcome measure was disease-specific
mortality. RESULTS: In the fully adjusted model, similar to the
relation of coffee intake to total mortality, the hazard ratio of
death attributed to cardiovascular disease was 0.76 (95% CI: 0.64,
0.91) for consumption of 1-3 cups/d, 0.81 (95% CI: 0.66, 0.99) for 4-5
cups/d, and 0.87 (95% CI: 0.69, 1.09) for > or =6 cups/d. The hazard
ratio for death from other inflammatory diseases was 0.72 (95% CI:
0.55, 0.93) for consumption of 1-3 cups/d, 0.67 (95% CI: 0.50, 0.90)
for 4-5 cups/d, and 0.68 (95% CI: 0.49, 0.94) for > or =6 cups/d.
CONCLUSIONS: Consumption of coffee, a major source of dietary
antioxidants, may inhibit inflammation and thereby reduce the risk of
cardiovascular and other inflammatory diseases in postmenopausal
women.
PMID: 16685044 [PubMed - indexed for MEDLINE |
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| Posted: Wed Jun 11, 2008 10:10 am |
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| Posted: Wed Jun 11, 2008 10:12 am |
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Br J Cancer. 2005 Sep 5;93(5):607-10. Links
Coffee and risk of death from hepatocellular carcinoma in a large
cohort study in Japan.Kurozawa Y, Ogimoto I, Shibata A, Nose T,
Yoshimura T, Suzuki H, Sakata R, Fujita Y, Ichikawa S, Iwai N,
Tamakoshi A; JACC Study Group.
Department of Social Medicine, Division of Health Administration and
Promotion, Faculty of Medicine, Tottori University, Nishimachi 86,
Yonago 683-8503, Japan. kurozawa at (no spam) grape.med.tottori-u.ac.jp
We examined the relation between coffee drinking and hepatocellular
carcinoma (HCC) mortality in the Japan Collaborative Cohort Study for
Evaluation of Cancer Risk (JACC Study). In total, 110,688 cohort
members (46,399 male and 64,289 female subjects) aged 40-79 years were
grouped by coffee intake into three categories: one or more cups per
day, less than one cup per day and non-coffee drinkers. Cox
proportional hazards model by SAS was used to obtain hazard ratio of
HCC mortality for each coffee consumption categories. The hazard
ratios were adjusted for age, gender, educational status, history of
diabetes and liver diseases, smoking habits and alcohol. The hazard
ratio of death due to HCC for drinkers of one and more cups of coffee
per day, compared with non-coffee drinkers, was 0.50 (95% confidence
interval 0.31-0.79), and the ratio for drinkers of less than one cup
per day was 0.83 (95% confidence interval 0.54-1.25). Our data
confirmed an inverse association between coffee consumption and HCC
mortality.
PMID: 16091758 [PubMed - indexed for MEDLINE] |
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