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Science Forum Index » Life Extension Forum » Aging and dietary restriction effects on...
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 Posted: Wed Jun 11, 2008 9:42 am |
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Mech Ageing Dev. 2008 Apr 30. [Epub ahead of print] Links
Aging and dietary restriction effects on ubiquitination, sumoylation,
and the proteasome in the heart.Li F, Zhang L, Craddock J, Bruce-
Keller AJ, Dasuri K, Nguyen A, Keller JN.
Sanders-Brown Center on Aging, University of Kentucky, Lexington, KY,
USA.
Dietary restriction (DR), in the absence of malnutrition, is the only
intervention known to reliably increase average and maximal lifespan
in a variety of organisms including mammals. Because the effects of DR
on the heart are poorly understood, in the present study we examined
the effects of DR on the ubiquitin-proteasome pathway (UPP) in the
heart. In these studies we observed that DR significantly reduced age-
related impairments in proteasome-mediated protein degradation, and
reduced age-related increases in ubiquitinated, oxidized, and
sumoylated protein in the heart. Interestingly, DR did not
significantly increase the expression of 20S proteasome subunits or
the proteasome maturation factor (POMP-1). These data demonstrate for
the first time the effects of aging and DR on proteasome biogenesis
and sumoylation in the heart. Cumulatively, our data indicate that DR
has many beneficial effects towards the UPP in the heart, and suggests
that a preservation of the UPP may be a potential mechanism by which
DR mediates beneficial effects on the cardiovascular system.
PMID: 18533226 [PubMed - as supplied by publisher] |
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