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Science Forum Index » Life Extension Forum » Free radical theory of aging: an update: increasing...
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 Posted: Wed Jun 11, 2008 9:34 am |
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Ann N Y Acad Sci. 2006 May;1067:10-21. Links
..Harman D.
Department of Medicine, University of Nebraska College of Medicine,
Nebraska Medical Center, Omaha, 68198-4635, USA. vcerino at (no spam) unmc.edu
Aging is the progressive accumulation of diverse, deleterious changes
with time that increase the chance of disease and death. The basic
chemical process underlying aging was first advanced by the free
radical theory of aging (FRTA) in 1954: the reaction of active free
radicals, normally produced in the organisms, with cellular
constituents initiates the changes associated with aging. The
involvement of free radicals in aging is related to their key role in
the origin and evolution of life. Aging changes are commonly
attributed to development, genetic defects, the environment, disease,
and an inborn aging process (IAP). The latter produces aging changes
at an exponentially increasing rate with age, becoming the major risk
factor for disease and death for humans after the age of 28 years in
the developed countries. In them the IAP limits human average life
expectancy at birth (ALE-B)--a rough measure of the healthy life span--
to about 85 years; few reach 100 years and only one is known to have
lived to 122 years. In these countries, improvements in living
conditions (ILC) have gradually raised ALE-Bs to 76-79 years, 6-9
years less than the limit imposed by aging, with no change in the
maximum life span (MLS). The extensive studies based on the FRTA hold
promise that ALE-B and the MLS can be extended, the ALE-B possibly by
a few years, and the MLS somewhat less.
PMID: 16803965 [PubMed - indexed for MEDLINE] |
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