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Science Forum Index » Life Extension Forum » Novel approaches to treat oxidative stress and...
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| rs1000b at (no spam) yahoo.com... |
 Posted: Fri Jun 06, 2008 7:38 am |
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Trans Am Clin Climatol Assoc. 2007;118:209-14.
Novel approaches to treat oxidative stress and cardiovascular
diseases.
Berk BC.
Cardiovascular Research Institute and Department of Medicine,
University of Rochester School of Medicine and Denistry, Rochester, NY
14642.
Reduction-oxidation (redox) reactions that generate reactive oxygen
species (ROS) such as hydrogen peroxide and superoxide have been
identified as important chemical processes that regulate signal
transduction. The findings of increased ROS in association with
endothelial dysfunction has given rise to the "antioxidant
hypothesis": since ROS are increased in hypertension, atherosclerosis
and vascular injury, then inhibiting oxidative stress with
antioxidants should decrease cardiovascular events. Preliminary
efforts with antioxidant vitamins like beta-carotene, vitamin C and
vitamin E have shown no clinical benefits. Here we discuss a specific
"redox signaling hypothesis." We propose that physiologic stimuli such
as steady laminar flow regulate the redox state of cells and tissues
thereby modulating signaling molecules that are redox sensitive. Here
we show that steady laminar flow inhibits tumor necrosis factor (TNF)
signaling and inflammation in endothelial cells. We have identified a
specific redox molecule-thioredoxin interacting protein (TXNIP)-as a
key redox regulator of inflammation in blood vessels. We suggest that
modifying the redox state of the vasculature is an attractive
therapeutic approach if we target specific redox dependent pathways
such as TXNIP.
PMID: 18528504 [PubMed - in process] |
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