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Science Forum Index » Life Extension Forum » Telomerase does not counteract telomere shortening but...
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| rs1000b at (no spam) yahoo.com... |
 Posted: Thu Jun 05, 2008 5:02 pm |
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J Cell Sci. 2008 Apr 1;121(Pt 7):1046-53. Epub 2008 Mar 11.
Telomerase does not counteract telomere shortening but protects
mitochondrial function under oxidative stress.
Ahmed S, Passos JF, Birket MJ, Beckmann T, Brings S, Peters H, Birch-
Machin MA, von Zglinicki T, Saretzki G.
Crucible Laboratory, Institute for Ageing and Health, Newcastle
University, Newcastle upon Tyne, NE4 6BE, UK.
Telomerase is a ribonucleoprotein that counteracts telomere shortening
and can immortalise human cells. There is also evidence for a telomere-
independent survival function of telomerase. However, its mechanism is
not understood. We show here that TERT, the catalytic subunit of human
telomerase, protects human fibroblasts against oxidative stress. While
TERT maintains telomere length under standard conditions, telomeres
under increased stress shorten as fast as in cells without active
telomerase. This is because TERT is reversibly excluded from the
nucleus under stress in a dose- and time-dependent manner.
Extranuclear telomerase colocalises with mitochondria. In TERT-
overexpressing cells, mtDNA is protected, mitochondrial membrane
potential is increased and mitochondrial superoxide production and
cell peroxide levels are decreased, all indicating improved
mitochondrial function and diminished retrograde response. We propose
protection of mitochondria under mild stress as a novel function of
TERT.
PMID: 18334557 [PubMed - in process] |
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