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Science Forum Index » Medicine - Cardiology Forum » Iron Removal and Atherosclerosis...
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| ironjustice... |
 Posted: Fri May 23, 2008 6:38 pm |
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Guest
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"Iron chelators may be effective in preventing vascular damage"
Hemoglobin. 2008;32(1-2):123-34
Can iron chelators influence the progression of atherosclerosis?
Marx JJ, Kartikasari AE, Georgiou NA.
Eijkman Winkler Institute, University Medical Centre Utrecht, Utrecht,
The Netherlands. marx at (no spam) planet.nl
Epidemiological studies and experimental data suggest iron involvement
in atherosclerosis.
The relation between iron and atherosclerosis is complex and remains
contradictory.
In thalassemia patients, non transferrin bound iron (NTBI) and free
hemoglobin (Hb) are present in plasma and may accelerate
atherogenesis, but its progression may be inhibited by iron
chelators.
The mechanism whereby iron may stimulate atherogenesis has been
intensively investigated.
Non transferrin bound iron and sera from subjects with hemochromatosis
induced endothelial activation with expression of vascular adhesion
molecules and endothelial inflammatory chemokines.
Such events could be inhibited by iron chelators and oxygen radical
scavengers with intracellular activity.
Iron chelators may be effective in preventing vascular damage in
patients with high concentrations of NTBI as found in thalassemia.
Publication Types:
Review
PMID: 18274990 [PubMed - indexed for MEDLINE]
Who loves ya.
Tom
Jesus Was A Vegetarian!
http://tinyurl.com/2r2nkh
Man Is A Herbivore!
http://tinyurl.com/a3cc3
DEAD PEOPLE WALKING
http://tinyurl.com/zk9fk |
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| ironjustice... |
| Posted: Fri May 23, 2008 7:04 pm |
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On May 23, 9:38 pm, ironjustice <teamtan... at (no spam) hotmail.com> wrote:iron
chelator <<
This would give evidence to the iron being involved because this drug
probucol is a proven iron chelator and seems to provide the same
benefit.
----------------
Anti-atherosclerotic and anti-diabetic properties of probucol and
related compounds
Authors: Tanous, David1; Hime, Neil2; Stocker, Roland3
Source: Redox Report, Volume 13, Number 2, April 2008 , pp. 48-59(12)
Abstract:
Probucol is a diphenolic compound with anti-oxidant and anti-
inflammatory properties that reduces atherosclerosis and restenosis.
Unfortunately, adverse effects on blood lipoproteins and cardiac
electrophysiology have curtailed its use as a drug.
Compounds related to probucol that have improved efficacy without the
adverse effects offer promise as novel therapies of cardiovascular
disease.
Recent results suggest that these compounds may be used for the
prevention of type 2 diabetes, a disease that is increasing in
prevalence and importance world-wide.
In this review, the molecular mechanisms underlying the beneficial
activities of probucol and related compounds are described.
Keywords: PROBUCOL; TYPE 2 DIABETES; ATHEROSCLEROSIS
Document Type: Review article
DOI: 10.1179/135100008X259196
Affiliations: 1: Toronto Congenital Cardiac Centre for Adults,
Toronto
General Hospital, University Health Network, Toronto, Canada 2:
Centre
for Vascular Research, Bosch Institute and Discipline of Pathology,
The University of Sydney, Sydney, New South Wales, Australia 3:
Centre
for Vascular Research, Bosch Institute and Discipline of Pathology,
The University of Sydney, Sydney, New South Wales, Australia.
rstoc... at (no spam) med.usyd.edu.au
----------------------------------
http://tinyurl.com/ynpdhm
"Iron-chelating agents, N-acetyl-L-cysteine (NAC), apocynin,probucol,
and edaravone, are useful in preventing cardiovascular injury and
diseases."
Recent Patents on Anti-Infective Drug Discovery, 2006, 1,
17-31171574-891X/06 $100.00+.00(c) 2006 Bentham Science Publishers
Ltd.Recent Progress in Pharmacological Research of Antioxidants
inPathological Conditions: Cardiovascular Health
---------------------------------
http://www.msnbc.msn.com/id/23578106/
Could foods help prevent ovarian cancer?
Flavonoids found in tea, veggies, fruits and beans could lower risk
Sena Vidanagama / Diets high in certain flavonoid compounds found in
tea, vegetables, fruits and beans may significantly lower a woman's
risk of developing ovarian cancer.
Cancer prevention is important, but it is particularly crucial for
those types of cancer not easily detected early. Ovarian cancer, for
example, often has no symptoms in early stages and is frequently
diagnosed at a more advanced stage, resulting in poorer survival
rates
than other cancers.
But could natural compounds in plant-based foods help to prevent
ovarian cancer?
A new study suggests that diets high in certain flavonoid compounds
found in vegetables, fruits, beans and tea may significantly lower a
woman's risk of developing ovarian cancer.
Flavonoids are a large family of antioxidant compounds known as
phytochemicals. They are part of a plant's natural defense system
that
helps the plant fight off disease and infection.
Lowered disease risk
Research suggests these compounds could help prevent a variety of
diseases in humans -- including cancer -- by protecting cells from
DNA
damage. Scientists believe some flavonoids may also deter cancer
development by helping to regulate cell growth and fight inflammation
or by changing hormone levels.
A new study, published in the International Journal of Cancer in
2007,
involved almost 67,000 women in the Nurses' Health Study and looked
at
flavonoid consumption over 14 years. Although total flavonoid
consumption was not shown as related to the risk of developing
ovarian
cancer, two particular flavonoids were.
Kaempferol -- a flavonoid found in tea, broccoli, kale and spinach --
and luteolin -- which is provided by peppers, carrots, cabbage and
celery -- were both identified as cancer protective. Women who
consumed
the most of these two flavonoids were 40 percent and 34 percent less
likely, respectively, to develop ovarian cancer compared to women who
consumed the least. Participants who consumed high levels of a third
phytochemical, myricetin (found in tea, dried beans, raisins and
blueberries), also seemed somewhat protected.
Flavonoid compounds found in vegetables may be part of what's behind
an apparent link between vegetable consumption and lower risk of
ovarian cancer. A landmark report on diet and cancer risk published
by
the American Institute for Cancer Research in 2007 noted that some
evidence suggests that non-starchy vegetables may offer protection
against ovarian cancer. The report emphasizes that protection could
come from any of several families of phytochemicals, as well as
dietary fiber, vitamins and minerals.
Keep eating those veggies
Researchers note that determining the relative importance of one
individual constituent in a food is difficult. A protective effect is
likely the result of a combination of influences on several pathways
involved in cancer development.
Evidence that supports phytochemicals' role in fighting ovarian
cancer
is growing. A 2007 study published in the British Journal of
Nutrition
linked greater consumption of carotenoid phytochemicals with a 67
percent lower risk of ovarian cancer. This included not only beta-
carotene, the oft-cited carotenoid in deep-orange vegetables and
fruits, but also alpha-carotene, beta-cryptoxanthin, lutein and
zeaxanthin -- carotenoids found in a wide range of red, orange,
yellow
and green vegetables. This research echoed an earlier study, which
showed a reduction in ovarian cancer risk of greater than 50 percent
among top vegetable consumers.
Although the research is promising, for now women are best advised
not
to focus on a single potential link highlighted in one or two
studies,
but to follow current guidelines to lower overall cancer risk.
General
recommendations include following a diet that provides a wide variety
of vegetables and other plant-based foods, exercising regularly and
controlling weight.
(c) 2008 MSNBC Interactive
-------------------------------
J. Phys. Chem. B, 112 (6), 1845 -1850, 2008. 10.1021/jp076881e
S1520-6106(07)06881-2
Web Release Date: January 23, 2008
Copyright (c) 2008 American Chemical Society
Complexation of Flavonoids with Iron: Structure and Optical
Signatures
Jun Ren, Sheng Meng, Ch. E. Lekka, and Efthimios Kaxiras*
Department of Physics and School of Engineering and Applied Sciences,
Harvard University, Cambridge, Massachusetts 02138, and Department of
Materials Science and Engineering, University of Ioannina, Ioannina
45110, Greece
Received: August 28, 2007
In Final Form: October 31, 2007
Abstract:
Flavonoids exhibit antioxidant behavior believed
to be related to their metal ion chelation ability.
We investigate the complexation mechanism
of several flavonoids, quercetin, luteolin, galangin,
kaempferol, and chrysin, with iron, the most abundant
type of metal ions in the body, through first-principles
electronic structure calculations based on density
functional theory (DFT).
We find that the most likely chelation site for Fe is the
3-hydroxyl-4-carbonyl group, followed by 4-carbonyl-5-hydroxyl
group and the 3'-4' hydroxyl (if present) for all of the flavonoid
molecules studied.
Three quercetin molecules are required to saturate the bonds
of a single Fe ion by forming six orthogonal Fe-O bonds, though
the binding energy per molecule is highest for complexes
consisting of two quercetin molecules and one Fe atom, in
agreement with experiment.
Optical absorption spectra calculated with time-dependent DFT
serve as signatures to identify various complexes.
For the iron-quercetin complexes, we find a redshift of the first
absorbance peak upon complexation in good agreement with
experiment; this behavior is explained by the narrowing of the
optical gap of quercetin because of Fe(d)-O(p) orbital hybridization.
---------------------------------------------------------------------------------
Who loves ya.
Tom
Jesus Was A Vegetarian!
http://jesuswasavegetarian.7h.com
Man Is A Herbivore!
http://tinyurl.com/a3cc3
DEAD PEOPLE WALKING
http://tinyurl.com/zk9fk
Quote: "Iron chelators may be effective in preventing vascular damage"
Hemoglobin. 2008;32(1-2):123-34
Can iron chelators influence the progression of atherosclerosis?
Marx JJ, Kartikasari AE, Georgiou NA.
Eijkman Winkler Institute, University Medical Centre Utrecht, Utrecht,
The Netherlands. m... at (no spam) planet.nl
Epidemiological studies and experimental data suggest iron involvement
in atherosclerosis.
The relation between iron and atherosclerosis is complex and remains
contradictory.
In thalassemia patients, non transferrin bound iron (NTBI) and free
hemoglobin (Hb) are present in plasma and may accelerate
atherogenesis, but its progression may be inhibited by iron
chelators.
The mechanism whereby iron may stimulate atherogenesis has been
intensively investigated.
Non transferrin bound iron and sera from subjects with hemochromatosis
induced endothelial activation with expression of vascular adhesion
molecules and endothelial inflammatory chemokines.
Such events could be inhibited by iron chelators and oxygen radical
scavengers with intracellular activity.
Iron chelators may be effective in preventing vascular damage in
patients with high concentrations of NTBI as found in thalassemia.
Publication Types:
Review
PMID: 18274990 [PubMed - indexed for MEDLINE]
Who loves ya.
Tom
Jesus Was A Vegetarian!http://tinyurl.com/2r2nkh
Man Is A Herbivore!http://tinyurl.com/a3cc3
DEAD PEOPLE WALKINGhttp://tinyurl.com/zk9fk |
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| J666... |
| Posted: Sat May 24, 2008 9:58 pm |
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Guest
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On Sat, 24 May 2008 10:51:01 -0500, ironjustice wrote
(in message
<e7c42587-019e-4c48-aba6-05077cfdf010 at (no spam) y21g2000hsf.googlegroups.com>):
Quote: You should write for .. Cole's ..
Do you like cole and does it have iron like spinach? |
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