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Science Forum Index » Life Extension Forum » Effects of D-003, a mixture of very long chain...
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| rs1000b at (no spam) yahoo.com... |
 Posted: Fri May 23, 2008 4:39 pm |
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Arzneimittelforschung. 2008;58(3):126-30.
Effects of D-003, a mixture of very long chain saturated fatty acids,
and policosanol on in vivo lipid peroxidation in rats.
Pérez Y, Más R, González RM, Jiménez S, Molina V.
Center of Natural Products, National Center for Scientific Research,
Havana City, Cuba. yohani.perez at (no spam) at (no spam) at (no spam) cnic.edu.cu
BACKGROUND: D-003 and policosanol (CAS 557-61-9), specific and
distinct mixtures of high molecular weight primary aliphatic acids and
alcohols, respectively, have shown to inhibit lipid peroxidation in
vivo, but comparative studies between their effects on lipid
peroxidation processes had not been conducted before. OBJECTIVE: To
compare the effects of D-003 and policosanol on markers of lipid
peroxidation in vivo in rats. METHODS: Male Wistar rats were
distributed into 9 groups: a control group treated with acacia gum/
water vehicle, 4 with policosanol and 4 with D-003, both treatments at
5, 25, 100 and 250 mg/kg. Treatments were administered during 4 weeks.
RESULTS: Both treatments significantly and dose-dependently reduced
plasma malondyaldehide (MDA) and total peroxides. Nevertheless, while
D-003 was effective from 5 mg/kg, the lowest effective dose of
policosanol was 25 mg/kg. The maximal effects of both treatments were
obtained with 100 mg/kg, but greater in D-003 than in policosanol
group, and the same occurred across all doses tested. MDA
concentrations generated with the enzymatic system in liver
homogenates were also significantly and dose-dependently inhibited
with both treatments. The lowest effective doses of D-003 and
policosanol were 5 and 100 mg/kg, respectively, and the highest
inhibitions of about 80% (D-003) and 11% (policosanol). D-003 was more
effective than policosanol in all comparisons. D-003 was also more
effective than policosanol for lowering MDA concentrations generated
with the no enzymatic system, but in these conditions policosanol was
effective from 25 mg/kg and produced an inhibition somewhat greater
(about 29%) than on MDA-generated by the enzymatic system. Both
policosanol and D-003 did not modify the activity of endogenous
antioxidant enzymes compared with the controls. CONCLUSIONS: D-003
(5-250 mg/kg) orally administered for 4 weeks was more effective than
policosanol for lowering all the lipid peroxidation markers assessed,
like plasma MDA and total peroxides, and MDA concentrations generated
by the enzymatic and non-enzymatic oxidant systems of liver
homogenates. The inhibitions with D-003 were marked and dose-
dependent. Neither D-003 nor policosanol modified the activity of
enzymes involved in the endogenic antioxidant defensive system.
PMID: 18488809 [PubMed - in process] |
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