| |
 |
|
|
Science Forum Index » Life Extension Forum » Longevity and resistance to stress correlate with DNA...
Page 1 of 1
|
| Author |
Message |
| ... |
 Posted: Thu May 15, 2008 11:56 am |
|
|
|
Guest
|
Nucleic Acids Res. 2008 Mar;36(4):1380-9. Epub 2008 Jan 18. Links
Longevity and resistance to stress correlate with DNA repair capacity
in Caenorhabditis elegans.Hyun M, Lee J, Lee K, May A, Bohr VA, Ahn B.
Department of Life Sciences, University of Ulsan 680-749, Korea.
DNA repair is an important mechanism by which cells maintain genomic
integrity. Decline in DNA repair capacity or defects in repair factors
are thought to contribute to premature aging in mammals. The nematode
Caenorhabditis elegans is a good model for studying longevity and DNA
repair because of key advances in understanding the genetics of aging
in this organism. Long-lived C. elegans mutants have been identified
and shown to be resistant to oxidizing agents and UV irradiation,
suggesting a genetically determined correlation between DNA repair
capacity and life span. In this report, gene-specific DNA repair is
compared in wild-type C. elegans and stress-resistant C. elegans
mutants for the first time. DNA repair capacity is higher in long-
lived C. elegans mutants than in wild-type animals. In addition, RNAi
knockdown of the nucleotide excision repair gene xpa-1 increased
sensitivity to UV and reduced the life span of long-lived C. elegans
mutants. These findings support that DNA repair capacity correlates
with longevity in C. elegans.
PMID: 18203746 [PubMed - indexed for MEDLINE]
PMCID: PMC2275101 |
|
|
| Back to top |
|
| ... |
| Posted: Thu May 15, 2008 11:57 am |
|
|
|
Guest
|
|
| Back to top |
|
| |
|
Page 1 of 1
All times are GMT - 5 Hours
The time now is Fri Dec 05, 2008 8:10 am
|
|