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Science Forum Index » Life Extension Forum » Zinc, metallothioneins, longevity: effect of zinc...
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 Posted: Wed May 14, 2008 12:05 pm |
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Rejuvenation Res. 2008 Apr;11(2):419-23. Links
Zinc, metallothioneins, longevity: effect of zinc supplementation on
antioxidant response: a zincage study.Mocchegiani E; and The Zincage
Consortium.
Immunolgy Center, Section of Nutrigenomics and Immunosenenscence, Res.
Dept. INRCA, Ancona, Italy.
ABSTRACT Aging is characterized by spontaneous biochemical changes
that may predispose to increased susceptibility to diseases. Zinc may
remodel these changes leading to healthy aging because zinc improves
antioxidant defense via CLU protein and genomic stability via PARP-1
nuclear enzyme and repairs oxidized proteins via Msr A protein. The
intracellular zinc homeostasis is regulated by metallothioneins (MT),
which are unable in zinc release in aging, causing impaired
antioxidant response restored by zinc supplementation. Here, the
choice of old subjects for zinc supplementation is discussed in
relation to their genetic background of MT and IL-6, because both
affect intracellular zinc homeostasis.
PMID: 18442325 [PubMed - in process] |
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