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Science Forum Index » Life Extension Forum » Apolipoprotein E, an important player in longevity and...
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 Posted: Wed May 14, 2008 11:58 am |
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Exp Gerontol. 2008 Apr 4 [Epub ahead of print] Links
Apolipoprotein E, an important player in longevity and age-related
diseases.Ang LS, Cruz RP, Hendel A, Granville DJ.
Numerous murine models are available for the study of the human aging
process. Most of these models are based on known mutations that cause
progeroid disease in humans or are involved in DNA repair and cell
senescence. While these models certainly have contributed to our
knowledge of age-related diseases, none adequately represent the range
of human ailments involving cardiovascular and neurocognitive
deterioration. In the current review, we summarize the available
murine models of aging to date. We then discuss the known involvement
of apolipoprotein E (ApoE) in various symptoms of the human aging
process and describe the corresponding age-related phenotypes
presented by the ApoE knockout mouse.
PMID: 18468826 [PubMed - as supplied by publisher] |
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