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Science Forum Index » Life Extension Forum » Suppressive effects of flavonoid fisetin on...
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 Posted: Wed May 14, 2008 11:30 am |
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Fisetin is a sirtuin activator with a weaker effect than resveratrol.
Int Immunopharmacol. 2008 Mar;8(3):484-94. Epub 2008 Jan 16. Links
Suppressive effects of flavonoid fisetin on lipopolysaccharide-induced
microglial activation and neurotoxicity.Zheng LT, Ock J, Kwon BM, Suk
K.
Department of Pharmacology, School of Medicine, Brain Science and
Engineering Institute, CMRI, Kyungpook National University, Daegu,
Republic of Korea.
Microglia are innate immune cells in the central nervous system.
Activation of microglia plays an important role in the processes of
several neurodegenerative diseases including Alzheimer's disease,
Parkinson's disease, and HIV dementia. Activated microglia can produce
various proinflammatory cytokines and nitric oxide (NO), which may
exert neurotoxic effects. Inhibition of microglia activation may
alleviate neurodegeneration under these conditions. To search for the
novel therapeutic agents against neuroinflammatory diseases, we have
screened a series of flavonoid compounds using a cell-based assay. Our
studies showed that fisetin markedly suppressed the production of
tumor necrosis factor (TNF)-alpha, NO, and prostaglandin (PG) E2 in
lipopolysaccharide (LPS)-stimulated BV-2 microglia cells or primary
microglia cultures. Fisetin also inhibited the gene expression of TNF-
alpha, interleukin (IL)-1 beta, cyclooxygenase (COX-2) and inducible
nitric oxide synthase (iNOS) at both mRNA and protein levels. Fisetin
significantly suppressed I kappa B degradation, nuclear translocation
of NF-kappa B, and phosphorylation of p38 mitogen-activated protein
kinase (MAPKs) in the LPS-stimulated BV-2 microglia cells. In
addition, fisetin reduced cytotoxicity of LPS-stimulated microglia
toward B35 neuroblastoma cells in a co-culture system. These results
indicate that fisetin has a strong anti-inflammatory activity in brain
microglia, and could be a potential therapeutic agent for the
treatment of neuroinflammatory diseases.
PMID: 18279803 [PubMed - indexed for MEDLINE] |
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