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Mark Wexler...
Posted: Thu May 15, 2008 1:52 am
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Let's say I do an experiment on N subjects, and for each subject I
have a measurement m_1, ..., m_N. To do a bootstrap resample, I choose
N measurements, with replacement.

OK, now let's say that for each subject, I actually have a bunch of
complicated measurements, from which I can calculate the most probable
m_i. But in reality, for each subject I have a distribution for his or
her m_i, let's call it D_i. These distributions are not the same: for
some subjects D_i are sharply peaked, so that I know m_i with high
precision, while for others the D_i are highly spread out, so that the
corresponding m_i are known with low precision.

So how do I do a bootstrap resample on this kind of data? I can think
of three possibilities:
1. As before, I choose N subjects with replacement, and for each
subject i, I choose his or her most likely m_i.
2. I keep my original N subjects, but for each subject I choose an
m_i* from his or her individual distribution D_i.
3. A combination: I choose N random subjects (with replacement), and
for each subject i I choose a random m_i from his or her distribution
D_i.

I anyone has any insight on this question, I'd really appreciate it.

Mark Wexler
 
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