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Science Forum Index » Life Extension Forum » DNA double-strand breaks: A potential causative factor...
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 Posted: Fri May 16, 2008 2:09 pm |
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Mech Ageing Dev. 2008 Feb 14. [Epub ahead of print] Links
DNA double-strand breaks: A potential causative factor for mammalian
aging?Li H, Mitchell JR, Hasty P.
Department of Molecular Medicine, Institute of Biotechnology,
University of Texas Health Science Center, 15355 Lambda Drive, San
Antonio, TX 78245-3207, United States.
Aging is a pleiotropic and stochastic process influenced by both
genetics and environment. As a result the fundamental underlying
causes of aging are controversial and likely diverse. Genome
maintenance and in particular the repair of DNA damage is critical to
ensure longevity needed for reproduction and as a consequence
imperfections or defects in maintaining the genome may contribute to
aging. There are many forms of DNA damage with double-strand breaks
(DSBs) being the most toxic. Here we discuss DNA DSBs as a potential
causative factor for aging including factors that generate DNA DSBs,
pathways that repair DNA DSBs, consequences of faulty or failed DSB
repair and how these consequences may lead to age-dependent decline in
fitness. At the end we compare mouse models of premature aging that
are defective for repairing either DSBs or UV light-induced lesions.
Based on these comparisons we believe the basic mechanisms responsible
for their aging phenotypes are fundamentally different demonstrating
the complex and pleiotropic nature of this process.
PMID: 18346777 [PubMed - as supplied by publisher]
Related ArticlesRepair of radiation-induced DNA double-strand breaks
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associated with human genomic disorders. [Mutat Res. 2005] Deletion of
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induced DSBs. [Mech Ageing Dev. 2007] Regulation of DNA double-strand
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DNA double-strand breaks. [Carcinogenesis. 2002] » See all Related
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