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Science Forum Index » Immunology Forum » tuberculosis and the DHEA to cortisol ratio
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| James Michael Howard |
 Posted: Tue Jun 26, 2007 8:04 am |
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Guest
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Scand J Immunol. 2007 Jul;66(1):97-103.
Altered Cortisol/DHEA Ratio in Tuberculosis Patients and its
Relationship with Abnormalities in the Mycobacterial-driven Cytokine
Production by Peripheral Blood Mononuclear Cells.
Bozza VV, D'Attilio L, Mahuad CV, Giri AA, Del Rey A, Besedovsky H,
Bottasso O, Bay ML.
Instituto de Inmunología, Facultad de Ciencias Médicas, Universidad
Nacional de Rosario, Rosario, Argentina.
We have investigated the relationship between cortisol and
dehydroepiandrosterone (DHEA) levels and the immune response to
mycobacterial antigens in peripheral venous blood, from a male population
of active tuberculosis patients and age-matched healthy controls of the
same sex (HCo). Peripheral blood mononuclear cells were cultured for 36 or
96 h with whole sonicated Mycobacterium tuberculosis (WSA) for measurement
of proliferation, interferon gamma (IFN-gamma) and interleukin-10 (IL-10)
in culture supernatants. Comparisons on the in vitro mycobacterial-driven
immune responses demonstrated that TB patients had a higher IL-10
production, a decreased lymphoproliferation and a trend to reduced
IFN-gamma synthesis, in relation to HCo. Active disease was also
characterized by increases in the plasma levels of glucocorticoids (GC) and
reduced concentrations of DHEA which resulted in a higher cortisol/DHEA
ratio respect the HCo group. Plasma DHEA levels were positively correlated
with IFN-gamma values. An inverse correlation was found between the
cortisol/DHEA ratio and IFN-gamma levels. Novel evidence is provided
showing that the balance between cortisol and DHEA is partly responsible
for the immune perturbations seen in TB patients. |
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