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| Science Forum Index » Life Extension Forum » Tissue glutathione and cysteine levels in methionine-restric |
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| Guest |
 Posted: Fri Sep 23, 2005 3:52 pm |
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Nutrition. 2004 Sep;20(9):800-5. Related Articles, Links
Tissue glutathione and cysteine levels in methionine-restricted rats.
Richie JP Jr, Komninou D, Leutzinger Y, Kleinman W, Orentreich N,
Malloy V, Zimmerman JA.
Division of Epidemiology and Cancer Susceptibility, American Health
Foundation Cancer Center, Institute for Cancer Prevention, Valhalla, NY
10595, USA. jrichie@ifcp.us
OBJECTIVE: Previously, we demonstrated that lifelong methionine (Met)
restriction (MR) increases lifespan, decreases the incidence of
aging-related diseases, increases blood glutathione (GSH) levels, and
prevents loss of GSH during aging in rats. Our present objective was to
elucidate the effects of MR on GSH metabolism and transport by
determining the time course and nature of GSH and cysteine changes in
blood and other tissues in young and mature rats. METHODS: Male F-344
rats were placed on control (0.86% Met) or MR (0.17% Met) defined amino
acid diets at age 7 wk and killed at different times thereafter. MR was
also initiated in adult (12-mo-old) rats. RESULTS: Throughout the first
2 mo of MR, blood GSH levels increased 84% and liver GSH decreased 66%
in relation to controls. After this period, liver GSH levels remained
constant through at least 6 mo. GSH levels also decreased in the
pancreas (80%) and kidney (22%) but remained unchanged in other tissues
examined after 11 wk of MR. The increase in blood GSH was evident as
soon as 1 wk after initiating MR and reached a plateau by 6 wk. A
similar increase in erythrocyte GSH levels was observed when MR was
administered to mature adult rats. Fasting decreased liver GSH in
controls but had no further effect in MR animals. By 1 mo, cysteine
levels had decreased in all tissues except brain. CONCLUSION: These
results suggest that adaptive changes occur in the metabolism of Met,
cysteine, and/or GSH as a result of MR in young and adult rats. These
early metabolic changes lead to conservation of GSH levels in most
extrahepatic tissues and increased GSH in erythrocytes by depleting
liver GSH to a critical level.
PMID: 15325691 [PubMed - indexed for MEDLINE] |
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| Guest |
| Posted: Sun Sep 25, 2005 9:57 pm |
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Does this mean that supplementing with S-AME, which puts methionine
into the body, can have bad effects? |
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| Paul Antonik Wakfer |
| Posted: Mon Sep 26, 2005 2:41 pm |
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Guest
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gehayw@hotmail.com wrote:
[quote:4e5d649459]Does this mean that supplementing with S-AME, which puts methionine
into the body, can have bad effects?
[/quote:4e5d649459]
No, Methionine is an essential amino acid obtained from many food sources.
The amount that would be obtained by conversion from supplemental SAMe
would be insignificant compared with dietary intake.
--Paul Wakfer
MoreLife for the rational - http://morelife.org
Reality based tools for more life in quantity and quality
The Self-Sovereign Individual Project - http://selfsip.org
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| Cruiser |
| Posted: Fri Oct 07, 2005 7:30 am |
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Guest
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| cruiser |
| Posted: Sun Oct 09, 2005 4:43 pm |
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Guest
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----- Original Message -----
From: "SDer" <sder@noland.com>
Newsgroups: sci.life-extension
Sent: Friday, October 07, 2005 5:42 PM
Subject: Re: Tissue glutathione and cysteine levels in methionine-restricted
rats.
[quote:8a3a70c626]
This was very interesting. Should NAC be accompanied by something as
well? like glutamine or selenium perhaps?
[/quote:8a3a70c626]
The one that I use also contains 50mcg Molybdenum and 25mcg selenium.
Cruiser |
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