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Science Forum Index » Life Extension Forum » ALA restores antioxidant system in tissues of hyperinsulinae
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| rs |
 Posted: Thu Jan 08, 2004 8:01 pm |
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Indian J Med Res. 2003 Sep;118:134-40.
Lipoic acid restores antioxidant system in tissues of
hyperinsulinaemic rats.
Thirunavukkarasu V, Anitha Nandhini AT, Anuradha CV.
Department of Biochemistry, Faculty of Science, Annamalai University,
Annamalai Nagar, Tamil Nadu, India.
BACKGROUND & OBJECTIVES: Feeding rats with high fructose induces
insulin resistance, hyperinsulinaemia, elevation of blood glucose
level and impaired glucose tolerance. Oxidative stress plays a vital
role in pathology associated with insulin resistance. The present
study was to investigate the effects of alpha-lipoic acid (LA) on the
oxidant-antioxidant balance in liver and kidney of high fructose-fed
rats. METHODS: Male Wistar rats (170-180 g) were divided into six
groups. The control group received diet containing starch; the
fructose group was given a high fructose diet (>60% of total
calories); the third and fourth groups were given fructose diet and
administered with two different doses of lipoic acid as low dose (35
mg/kg body weight) and high dose (70 mg/kg bw) intraperitoneally using
olive oil as vehicle; the fifth group received control diet and was
administered with lipoic acid (70 mg/kg bw); the sixth group received
the control diet and olive oil. The rats were maintained in their
respective dietary regimen for 20 days. Lipid peroxidation indices and
antioxidant status in liver and kidney were quantitated. RESULTS: The
rats fed fructose showed increased levels of lipid hydroperoxides,
thiobarbituric acid reactive substances (TBARS), conjugated dienes,
and impaired antioxidant defence potential as evidenced by a decrease
in the levels of non-enzymatic and enzymatic antioxidants. Treatment
with LA to the fructose-fed rats mitigated these alterations and LA
was effective uniformly at both the closes. Increased lipid
peroxidation and inadequate antioxidant system are observed in the
high dose fructose-fed rats. INTERPRETATION & CONCLUSION: LA
administration restored the antioxidant potential and lowered lipid
peroxidation. These findings strengthen the utility of LA in the
management of insulin resistance and associated pathology.
PMID: 14700347 [PubMed - in process]
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=14700347&dopt=Abstract |
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