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Science Forum Index » Life Extension Forum » Athletes have lower pyruvate kinase, higher NADH dehydrogena
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| kofi |
 Posted: Mon Jan 12, 2004 10:50 pm |
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FASEB J. 2003 Oct;17(13):1812-9. Related Articles, Links
Click here to read
Serial analysis of gene expression in the skeletal muscle of
endurance athletes compared to sedentary men.
Yoshioka M, Tanaka H, Shono N, Snyder EE, Shindo M, St-Amand J.
Molecular Endocrinology and Oncology Research Center, Laval
University Medical Center (CHUL) and Laval University, 2705 Boul.
Laurier, Ste-Foy, Quebec G1V 4G2, Canada.
Physical exercise produces several adaptive changes in skeletal
muscle. However, the molecular mechanisms of these effects are poorly
understood. We performed serial analysis of gene expression (SAGE) to
quantify the global gene expression profile in sedentary and
endurance-trained muscle. A total of 10869 SAGE tags was sequenced and
represented 4727 genes. The genes most expressed in muscle are mainly
involved in contraction and energy metabolism. Thirty-three genes were
differentially expressed between endurance athletes and sedentary
individuals. Four genes such as myosin binding protein C fast-type,
glycogen phosphorylase, and pyruvate kinase were expressed less in
endurance athletes, whereas eight genes coding for expressed sequence
tag similar to (EST) crystallin alpha B, EST myosin light chain 2, EST
surfactant pulmonary-associated protein A1, EST thrombospondin, EST
fructose-bisphosphate aldolase A, EST cytochrome oxidase 1, NADH
dehydrogenase 3, and G8 protein were up-regulated. Most of the
up-regulated tags corresponded to novel genes. On the other hand,
different isoforms of fructose-bisphosphate aldolase A were also
differentially expressed. The current study underlying the most highly
expressed genes allows a better understanding of global muscle
characteristics in normal and endurance-trained individuals. Moreover,
the current data suggest novel candidate genes that may be responsible
for enhanced endurance performance.
PMID: 14519660 [PubMed - indexed for MEDLINE] |
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