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Science Forum Index » Life Extension Forum » Thymus Gland - important?
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| Julian Jackson |
 Posted: Fri Dec 19, 2003 10:36 am |
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Guest
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Hi everyone,
I've been reading up a little on the thymus gland and it seems
important to me, but I'm sure the assorted LE boffins here will know
more.
As it appears to atrophy with age, is there any way to
regrow/restimulate it?
What about the various "Thymus Extracts" from animal glands sold by a
number of nutritional supp purveyors...do they survive getting though
the digestive system or are they quackery?
regards
Julian |
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| Capitalist Pig |
| Posted: Sat Dec 20, 2003 2:45 am |
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On 19 Dec 2003 07:36:57 -0800, julianj@totalise.co.uk (Julian Jackson)
wrote:
Quote:
What about the various "Thymus Extracts" from animal glands sold by a
number of nutritional supp purveyors...do they survive getting though
the digestive system or are they quackery?
I take TG-100 to keep my TSH at around 1. Works well. |
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| Doug Brooks |
| Posted: Sat Dec 20, 2003 12:07 pm |
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Capitalist Pig wrote:
Quote: On 19 Dec 2003 07:36:57 -0800, julianj@totalise.co.uk (Julian Jackson)
wrote:
What about the various "Thymus Extracts" from animal glands sold by a
number of nutritional supp purveyors...do they survive getting though
the digestive system or are they quackery?
I take TG-100 to keep my TSH at around 1. Works well.
What was your TSH before taking TG-100? |
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| Capitalist Pig |
| Posted: Sat Dec 20, 2003 1:55 pm |
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On Sat, 20 Dec 2003 12:07:46 -0500, Doug Brooks <dont@want.spam.com>
wrote:
Quote:
Capitalist Pig wrote:
On 19 Dec 2003 07:36:57 -0800, julianj@totalise.co.uk (Julian Jackson)
wrote:
What about the various "Thymus Extracts" from animal glands sold by a
number of nutritional supp purveyors...do they survive getting though
the digestive system or are they quackery?
I take TG-100 to keep my TSH at around 1. Works well.
What was your TSH before taking TG-100?
Don't recall the exact value but it was within "normal" range somewhat
close to the upper limit. You need to work with a good integrative
medicine doctor to find the "optimal" value for you.
Have a look at the test you can get from GSDL:
http://www.gsdl.com/images/reportpdf/compthyroid.pdf
Ask this lab for a "referral" to a good integrative medicine doctor in
your area. |
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| rs |
| Posted: Mon Jan 12, 2004 9:48 pm |
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julianj@totalise.co.uk (Julian Jackson) wrote in message news:<f099582c.0312190736.1488061d@posting.google.com>...
Quote: Hi everyone,
I've been reading up a little on the thymus gland and it seems
important to me, but I'm sure the assorted LE boffins here will know
more.
As it appears to atrophy with age, is there any way to
regrow/restimulate it?
Gingko biloba and melatonin may have possible benefit.
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Mech Ageing Dev. 2003 Aug-Sep;124(8-9):977-83.
Effects of Ginkgo biloba extract (EGb 761) on hydroxyl radical-induced
thymocyte apoptosis and on age-related thymic atrophy and peripheral
immune dysfunctions in mice.
Tian YM, Tian HJ, Zhang GY, Dai YR.
Department of Biological Sciences and Biotechnology, Tsinghua
University, Beijing 100084, PR China.
In this study, the effect of EGb 761, a standard extract of Ginkgo
biloba leaf, on thymocyte apoptosis and age-related thymic atrophy and
on peripheral immune dysfunctions was investigated in mice. When
primary culture of thymocytes was preincubated with 100 microg/ml EGb
761 before their exposure to hydroxyl radicals (*OH) generated by
Fe(2+)-mediated Fenton reaction, apoptotic cell death induced by *OH
was distinctly prevented as determined by DNA laddering, the TUNEL
assay and flow cytometric analysis. Furthermore, oral EGb 761
administration (about 1.5 mg/day/mouse) for 60 consecutive days led to
a significant thymic regrowth in 22-month-old mice as revealed by the
increment of thymus weight and total numbers of thymocytes. Partial
recovery of peripheral immune capacities such as mitogen
responsiveness and NK cell activity were also found in the old mice
after 60 days of EGb 761 supplementation. Taken together, our study
indicates that in addition to its protective and rescuing abilities on
neurodegenerative disorders and cardiovascular diseases, EGb 761 was
also found active in the rejuvenation of degenerated thymus and
accordingly the strengthening of the immune system. These beneficial
effects of EGb 761 on immune system are based on its antioxidant
properties as well as the cell proliferation-stimulating effect.
PMID: 14499503 [PubMed - in process]
===========================================
///////////////////////////////////////////
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Immunol Lett. 2003 Aug 5;88(2):101-4.
Melatonin rejuvenates degenerated thymus and redresses peripheral
immune functions in aged mice.
Tian YM, Zhang GY, Dai YR.
Department of Biological Sciences and Biotechnology, Tsinghua
University, Beijing 100084, China.
The effect of melatonin on age-related thymic involution and
peripheral immune dysfunctions was investigated. Exogenous melatonin
was administered through the drinking water (15 microg/ml) of
22-month-old female C57BL mice for 60 consecutive days. Our results
show that melatonin distinctly reversed the age-related thymic
involution as revealed by the notable increase of thymus weight, total
number of thymocytes and percentage of thymocytes at G2+S phases. More
strikingly, spleen weight, total number of splenocytes and some
peripheral immune capacity such as mitogen responsiveness and NK cell
activity were also significantly recovered by 60 days of melatonin
application in aged mice. Our findings demonstrate that even when the
melatonin supplementation begins late in life, the age-related thymic
involution and peripheral immune dysfunctions can be restored at least
partially in old mice.
PMID: 12880677 [PubMed - in process]
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=12880677&dopt=Abstract |
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