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Science Forum Index » Life Extension Forum » Induction of insulin secretion by Urtica dioica
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| rs |
 Posted: Mon Jan 12, 2004 9:30 pm |
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J Ethnopharmacol. 2003 Nov;89(1):47-53.
Induction of insulin secretion by a component of Urtica dioica leave
extract in perifused Islets of Langerhans and its in vivo effects in
normal and streptozotocin diabetic rats.
Farzami B, Ahmadvand D, Vardasbi S, Majin FJ, Khaghani Sh.
Department of Medical Biochemistry, Tehran University of Medical
Sciences, P.O. Box 14155-5399, Tehran, Iran. Bfarzamj@neda.net
The blood glucose lowering effect of Urtica dioica (Stinging Nettle)
as a medicinal plant has been noted in old writings such as those of
Avicenna. Recently, there has also been other investigators that
indicated the hypoglycemic effect of Urtica dioica. But so far, the
mechanism of this effect has not been deduced. In this report, a
perifusion system is arranged in which an exact number of Langerhans
Islets were exposed to several fractions of extracts of Urtica dioica
by TLC. The active ingredient fraction named F(1), caused a marked
increase in insulin secretion. A simultaneous assay of glucose showed
that the increase in insulin level was associated with a decrease in
glucose level. Furthermore, the active component of Urtica dioica was
found to increase the insulin content of blood sera in normal and
streptozotocin diabetic rats that were injected intraperitoneally
(i.p.) with the active ingredient of the extract. The in vivo studies
presented in this report show that not only an increase in insulin
level of blood sera was observed in rats after 30 min from the initial
point of injection but a simultaneous decrease of blood sugar was
detected when similar sera was tested for glucose. The increase in
insulin level was six times during the 120 min of our determination.
The decrease in blood sugar was found to be similar both in the level
and time of initiation. On the basis of our findings, we assume that
F(1) is the active ingredient of plant leaves extract. The results
show that the blood lowering effect of the extract was due to the
enhancement of insulin secretion by Langerhance Isletes.
PMID: 14522431 [PubMed - in process]
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=14522431&dopt=Abstract |
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