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Science Forum Index » Life Extension Forum » Positive effects of deprenyl and estradiol on spatial memory
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| rs |
 Posted: Thu Jan 08, 2004 7:55 pm |
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Neurosci Lett. 2004 Jan 16;354(3):225-8.
Positive effects of deprenyl and estradiol on spatial memory and
oxidant stress in aged female rat brains.
Kiray M, Uysal N, Sonmez A, Acikgoz O, Gonenc S.
Department of Physiology, Dokuz Eylul University Medical School,
Balcova, 35340, Izmir, Turkey
Increasing age decreases spatial learning and memory. Spatial learning
is coordinated with different brain regions. Since the oxidative
damage may play a role in the aging process, including the associated
cognitive decline, age-related impairment in spatial learning and
memory may be alleviated by antioxidant treatment. The present study
examined the effects of the monoamine oxidase B inhibitor L-deprenyl,
alone and in combination with estradiol, on spatial memory using the
Morris water maze and oxidant stress in aged female rat brains. We
demonstrated that co-administration of deprenyl and estradiol caused a
synergistic effect on spatial memory. However, use of either deprenyl
or estradiol alone increased antioxidant enzyme activities in brain
and reduced lipid peroxidation. Therefore, positive effects of
deprenyl and estradiol on spatial memory may occur due not only to
their antioxidant activities but also to the different actions.
PMID: 14700737 [PubMed - in process]
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=14700737&dopt=Abstract |
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