Effects of an oral mixture containing glycine, glutamine and

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mark boucher

Posted: Fri Jan 02, 2004 8:46 pm

Guest

The below study, was copied and pasted, from Yahoo.Morelife, as
requested By Paul Antonik Wakfer.

Date: Tue Dec 30, 2003 6:49 pm
Subject: Effects of an oral mixture containing glycine, glutamine and
niacin on memory, GH and IGF-1 secretion in middle-aged and elderly
subjects.

Effects of an oral mixture containing glycine, glutamine and niacin
on memory, GH and IGF-I secretion in middle-aged and elderly subjects.

Arwert LI, Deijen JB, Drent ML.

Department of Endocrinology, VU University Medical Center, de
Boelelaan 1117, 1081 HVAmsterdam, The Netherlands.

Aging is associated with declining activity of the growth hormone-
insulin-like growth factor-I (GH-IGF-I) axis and with a decrease in
cognitive function. The stimulatory effect of an orally administered
nutritional supplement, mainly containing glycine, glutamine and
niacin on the GH-IGF-I axis and on mood and cognition was
investigated. Forty-two healthy subjects (14 men and 28 women, aged
40-76 years) were enrolled in a randomised, double blind, placebo-
controlled trial. They received 5 g of a nutritional supplement or
placebo, twice daily orally for a period of 3 weeks. At baseline and
after 3 weeks, blood was collected for measurement of serum GH and
IGF-I levels and mood and cognitive function were tested. The
nutritional supplement ingestion for 3 weeks was found to increase
serum GH levels with 70% relatively to placebo, whereas circulating
IGF-I levels did not change. Mean GH (+/- SD) increased in this group
from 3.23 (+/- 4.7 Cool

to 4.67 mU/l (+/- 5.27) (p = 0.03). GH increase
was not associated with improvement in mood or memory. Correlation
analyses, however, revealed that individual increases in IGF-I, but
not GH, were associated with improved memory and vigour. It is
concluded that an oral mixture of glycine, glutamine and niacin can
enhance GH secretion in healthy middle-aged and elderly subjects.

Marc

[Thanks for supplying this very interesting new result. But always
supply the
PMID number when you send an abstract, because that is what allows it
to be
easily called up from PubMed (this one is PMID:14609312).

This abstract is interesting for several reasons.
1) It is the first study since the Welbourne study of 1995
(PMID:7733028) which
clearly shows that oral glutamine increases GH in healthy people.
2) The increase in GH did not cause an increase in IGF-1 which is
generally the
active hormone for body growth which is increased by GH. However, this
increase
of GH without an increase in IGF-1 is precisely what happens during
calorie
restriction. This is good because the increase in IGF-1 may promote
the growth
of any nascent cancer.
3) OTOH, the correlation of increased IGF-1 with memory and vigour
(done on an
individual basis) is a corroberation of earlier studies which showed
that DHEA
(which generally increases IGF-1 without increasing GH) enhanced mood
and vigour
of experimental subjects.

Now it would be very nice if someone would do the work of getting or
consulting
the full paper to see what exactly was the composition of the 5 gram
twice per
day mixture which they gave the experimental subjects (and also
details on the
dosing method and time). A full .pdf file of the paper would be best.
Anyone who
wishes to volunteer for this task, send me email so that I can help
assure that
more than one person does not do it. --Paul]

[The entire Welbourne paper can be seen at:

http://optimalhealth.cia.com.au/welbourne1.html
http://optimalhealth.cia.com.au/welbourne2.html
http://optimalhealth.cia.com.au/welbourne3.html
http://optimalhealth.cia.com.au/welbourne4.html **Kitty]

Marc

Paul Wakfer

Posted: Sat Jan 03, 2004 10:59 pm

Guest

dheasulfate@videotron.ca (mark boucher) wrote in message news:<cd65249e.0401021746.70743b3e@posting.google.com>...

Quote:

The below study, was copied and pasted, from Yahoo.Morelife, as
requested By Paul Antonik Wakfer.

I did not *request* that Marc post it here. Mark had sent it to the
MoreLife Yahoo group and after recognizing and commenting on its
importance, I had suggested that *he* post it to sle so that *he*
could get the recognition and appreciation for *supplying* some
information instead of always merely *asking* for information.

--Paul Wakfer

MoreLife for the rational - http://morelife.org
Reality based tools for more life in quantity and quality
The Self-Sovereign Individual Project - http://selfsip.org
Rational freedom by self-sovereignty & social contracting

kofi

Posted: Sun Jan 04, 2004 5:59 am

Guest

Quote:

Effects of an oral mixture containing glycine, glutamine and niacin
on memory, GH and IGF-I secretion in middle-aged and elderly subjects.
...
The
nutritional supplement ingestion for 3 weeks was found to increase
serum GH levels with 70% relatively to placebo, whereas circulating
IGF-I levels did not change. Mean GH (+/- SD) increased in this group
from 3.23 (+/- 4.7 Cool

It's hard to tell because the dosages aren't mentioned, but it's quite
possible that the improvements in mood and memory came about because
glycline and glutamine enhanced the brain's inhibitory system. Frontal
lobe inhibition declines with age and results in fuzzy thinking,
depression and other cognitive 'disorders.' Recent research with a
GABAergic agonist improved recall among aged monkeys to youthful levels.
It's possible taking glutamine increased GABAergic transmission in the
brain (glutamine->GABA) and glycine is itself an inhibitory
neurotransmitter. While it's hard to ingest GABA and get it across the
blood-brain barrier, you can get its components and other inhibitory
agonists in: L-theanine, taurine, B-12 and magnesium (magnesium's a GABA
agonist and rapidly becoming my favorite metal; I like it much more than
mercury.)

As there's often a tradeoff between sex and lifespan, this is no
exception. The GABA-B agonist baclofen is used to treat priapism. (Saw
it on the sex ed cable channel so it must be true.)

Finally, a ketogenic diet would also help since it calms nerve by
reducing the oxidative stress associated with energy production.

mark boucher

Posted: Sun Jan 04, 2004 5:06 pm

Guest

tom@morelife.org (Paul Wakfer) wrote in message news:<4f0e9375.0401031959.67fa440@posting.google.com>...

Quote:

dheasulfate@videotron.ca (mark boucher) wrote in message news:<cd65249e.0401021746.70743b3e@posting.google.com>...
The below study, was copied and pasted, from Yahoo.Morelife, as
requested By Paul Antonik Wakfer.

I did not *request* that Marc post it here. Mark had sent it to the
MoreLife Yahoo group and after recognizing and commenting on its
importance, I had suggested that *he* post it to sle so that *he*
could get the recognition and appreciation for *supplying* some
information instead of always merely *asking* for information.

--Paul Wakfer

MoreLife for the rational - http://morelife.org
Reality based tools for more life in quantity and quality
The Self-Sovereign Individual Project - http://selfsip.org
Rational freedom by self-sovereignty & social contracting

--------------------------------------------------------------------------------

Paul, it was an *honest mistake*, and I don't think making any *honest
mistkake* makes me look *foolish* among sensible people, who
themselves make their own mistakes. This is pure common sense to me. I
doubt that there are people here that will see me as being *foolish*,
especially, because I thought I was doing you a favor, or if you
prefer trying to help. Everyone make mistake, whether you like it or
not, this is a fact of life. As to me, *I'd never critisize anyone for
trying to do a favor or nice gesture*. You're entitled to your
opinion, and so do I.

Marc

Gene Haywood

Posted: Sun Jan 04, 2004 11:44 pm

Guest

kofi <kofi@anon.un> wrote in message news:<kofi-15A97E.05001104012004@news02.west.earthlink.net>...

Quote:

to 4.67 mU/l (+/- 5.27) (p = 0.03). GH increase
was not associated with improvement in mood or memory. Correlation
analyses, however, revealed that individual increases in IGF-I, but
not GH, were associated with improved memory and vigour. It is
concluded that an oral mixture of glycine, glutamine and niacin can
enhance GH secretion in healthy middle-aged and elderly subjects.

It's hard to tell because the dosages aren't mentioned, but it's quite
possible that the improvements in mood and memory came about because
glycline and glutamine enhanced the brain's inhibitory system. Frontal
lobe inhibition declines with age and results in fuzzy thinking,
depression and other cognitive 'disorders.' Recent research with a
GABAergic agonist improved recall among aged monkeys to youthful levels.
It's possible taking glutamine increased GABAergic transmission in the
brain (glutamine->GABA) and glycine is itself an inhibitory
neurotransmitter. While it's hard to ingest GABA and get it across the
blood-brain barrier, you can get its components and other inhibitory
agonists in: L-theanine, taurine, B-12 and magnesium (magnesium's a GABA
agonist and rapidly becoming my favorite metal; I like it much more than
mercury.)

As there's often a tradeoff between sex and lifespan, this is no
exception. The GABA-B agonist baclofen is used to treat priapism. (Saw
it on the sex ed cable channel so it must be true.)

Finally, a ketogenic diet would also help since it calms nerve by
reducing the oxidative stress associated with energy production.

I thought glutamine (like glutamate) was an excitatory neurotransmitter.

anon

Posted: Mon Jan 05, 2004 9:41 am

Guest

Quote:

I thought glutamine (like glutamate) was an excitatory neurotransmitter.

It's a precursor both to GABA and glutamate. You can shift production
more towards GABA by supplementing with additional substances.

tonyr

Posted: Thu Jan 08, 2004 5:04 pm

Guest

On Mon, 05 Jan 2004 14:41:51 GMT, anon <anon@anon.anon> wrote:

Quote:

I thought glutamine (like glutamate) was an excitatory neurotransmitter.

It's a precursor both to GABA and glutamate. You can shift production
more towards GABA by supplementing with additional substances.

these shifts in emphasis interest me greatly. "metabolic pathways" is
an applicable phrase here.

Anon i simply cannot find enough information on the types of shifts
you mention .. do you have some links to info online?? ifso greatly
appreciated.

bon voyage

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And bad among the best of us
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