| |
 |
|
|
Science Forum Index » Life Extension Forum » Effects of statins on bone growth in transplant patients via
Page 1 of 1
|
| Author |
Message |
| kofi |
 Posted: Sat Jan 03, 2004 1:04 am |
|
|
|
Guest
|
Transplantation. 2003 Sep 15;76(5):869-71. Related Articles, Links
Click here to read
Skeletal reconstruction by vascularized allogenic bone
transplantation: effects of statin in rats.
Ohno T, Shigetomi M, Ihara K, Matsunaga T, Hashimoto T, Kawano H,
Sugiyama T, Kawai S.
Department of Orthopedic Surgery, Yamaguchi University School of
Medicine, Yamaguchi, Japan.
BACKGROUND: Some statins have been reported to suppress the immune
system and increase the expression of bone morphogenetic protein-2 gene
that plays a pivotal role in bone regeneration. METHODS: The effects of
cerivastatin on skeletal reconstruction by vascularized bone allograft
were investigated in a rat tibia-fibula graft model. After
transplantation, the recipient rats were treated with vehicle, low-dose
cerivastatin, high-dose cerivastatin, or cyclosporine A. RESULTS:
Transplanted bones treated with low-dose cerivastatin and vehicle failed
to unite with the recipient bones. In contrast, high-dose cerivastatin
induced the bone union as effectively as cyclosporine A. Histologically,
high-dose cerivastatin-treated transplanted bones were nonvital, but new
bone formation occurred at the outer layer of the nonvital cortex.
CONCLUSION: These results indicate that statins could promote fracture
healing. Because transplant recipients have the increased risks of
osteoporotic fracture and hypercholesterolemia, statins may be a good
choice in the treatment of these patients.
PMID: 14501870 [PubMed - indexed for MEDLINE] |
|
|
| Back to top |
|
| |
|
Page 1 of 1
All times are GMT - 5 Hours
The time now is Sat Oct 11, 2008 5:22 pm
|
|