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Science Forum Index » Life Extension Forum » Changing endocrine profile in aging men
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| kofi |
 Posted: Wed Dec 31, 2003 12:35 am |
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Clin Chem Lab Med. 2003 Jul;41(7):934-41. Related Articles, Links
Endocrine alterations in the aging male.
Elmlinger MW, Dengler T, Weinstock C, Kuehnel W.
University Hospital, Pediatric Endocrinology Section, Tuebingen,
Germany.
The recent increase in the elderly population, current health trends
and awareness of age-related changes in the male endocrine system, have
led to discussions about the role of the hormonal changes in the aging
process in males. Better prevention and treatment of suboptimal health
status and age-related diseases in aging men are based on an improved
understanding of aging, particularly of the significance of
age-associated hormonal changes. The aims of this study were 1) to
evaluate the age dependence of the serum concentrations of the following
important hormonal parameters in adult males using the IMMULITE 1
automated assay system (DPC, Los Angeles): testosterone,
dehydro-epiandrosterone sulfate (DHEAS), estradiol (E2), sex hormone
binding globulin (SHBG), lutropin (LH), follitropin (FSH), cortisol,
prolactin, thyroid stimulating hormone (TSH), free triiodothyronine
(fT3), free thyroxine (fT4) and the growth hormone-dependent parameters
insulin-like growth factor (IGF-I) and IGF-binding protein-3 (IGFBP-3)
and 2) to derive the following parameters: calculated free testosterone
(cFT), ratio of calculated free testosterone to total testosterone (%
cFT) and free androgen index (FAI). We found a significant decrease
between the 21-30-year age group and the > 70-year age group for total
testosterone (-42.4%), FAI (-65.5%), cFT (-60.0%), % cFT (-30.0%), DHEAS
(-71.9%), E2 (-35.4%), TSH (-23.6%), IGF-I (-40.3%) and IGFBP-3
(-26.5%). Since the decreases in the FAI and cFT were greater than that
of total testosterone and because these derived parameters reflect the
biologically active fraction of testosterone, FAI and cFT are better
markers for androgen deficiency in males. In contrast, a significant
increase with age was observed for SHBG (+61.2%), LH (+40.0%), FSH
(+98.3%) and cortisol (+54.2%). No significant alterations with age were
observed for prolactin, fT3 and fT4. The study demonstrates that
determining complete profiles of the androgenic, gonadotropic,
adrenocortical, thyroid, pituitary and growth hormone/IGF endocrine axes
in middle-aged and elderly men may be helpful in obtaining a correct
clinical diagnosis for various hormonal disorders.
PMID: 12940521 [PubMed - in process] |
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