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Science Forum Index » Life Extension Forum » sibutramine decreases testosterone, increases SHBG in PCOS
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| kofi |
 Posted: Wed Dec 31, 2003 12:31 am |
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Guest
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Fertil Steril. 2003 Nov;80(5):1199-204. Related Articles, Links
Click here to read
Sibutramine has a positive effect on clinical and metabolic
parameters in obese patients with polycystic ovary syndrome.
Sabuncu T, Harma M, Harma M, Nazligul Y, Kilic F.
Endocrinology and Metabolism Department, University of Harran,
Faculty of Medicine, Sanliurfa, Turkey.
OBJECTIVE: To evaluate the effectiveness of sibutramine therapy
alone and in combination with ethinyl estradiol-cyproterone acetate
(EE-CPA) on the clinical and metabolic parameters of obese women with
polycystic ovary syndrome (PCOS). DESIGN: Prospective randomized,
controlled study. SETTING: Endocrinology and gynecology clinics.
PATIENT(S): Forty obese women with PCOS. INTERVENTION(S): Group 1 was
treated with oral EE-CPA (35 microg-2 mg/day), group 2 with oral
sibutramine (10 mg/day), and group 3 with a combination of EE-CPA plus
sibutramine for 6 months. All groups were advised to consume a diet of
1200 kcal/day. MAIN OUTCOME MEASUREMENT(S): Measurements were performed
before and 6 months after treatment of body mass index, waist-to-hip
ratio, systolic and diastolic blood pressure, Ferriman-Gallwey hirsutism
score, total testosterone, free testosterone, sex hormone-binding
globulin, dihydroepiandrosterone sulfate (DHEAS), total cholesterol,
high-density lipoprotein cholesterol, low-density lipoprotein
cholesterol, triglyceride, glucose and insulin during oral glucose
tolerance test, and insulin sensitivity index; area under the curve for
glucose and insulin were obtained from OGTT. RESULT(S): Body mass index,
Ferriman-Gallwey hirsutism score, serum total testosterone, free
testosterone, and DHEAS levels were significantly decreased and SHBG was
significantly increased in all groups at the end of the study. WHR,
diastolic blood pressure, and serum triglyceride level were
significantly reduced only in the sibutramine group. CONCLUSION(S):
Sibutramine might have a positive effect on hyperandrogenemia, and
clinical and metabolic risk factors for cardiovascular disease in obese
women with PCOS.
Publication Types:
* Clinical Trial
* Randomized Controlled Trial
PMID: 14607575 [PubMed - indexed for MEDLINE] |
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