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Science Forum Index » Life Extension Forum » Growth hormone binding protein correlated to leptin, insulin
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| kofi |
 Posted: Wed Dec 31, 2003 12:04 am |
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Guest
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It would be nice to know what this says about longevity.
Clin Endocrinol (Oxf). 2003 Oct;59(4):482-6. Related Articles, Links
Click here to read
The gender differences in growth hormone-binding protein and leptin
persist in 80-year-old men and women and is not caused by sex hormones.
Bulow B, Ahren B, Fisker S, Dehlin O, Hagberg B, Jensen E, Svensson
T, Samuelsson G, Erfurth EM.
Department of Medicine, Lund University, Lund, Sweden.
OBJECTIVE: Leptin and growth hormone-binding protein (GHBP) both
show gender differences that might be explained by sex hormones. To
study the potential relevance of oestradiol and testosterone, we have
examined 80-year-old subjects in whom oestradiol is higher in men than
in women. The interrelationships between leptin, insulin, GHBP and fat
mass in this age group were also investigated. DESIGN AND SUBJECTS:
Ninety-four subjects (55 females and 39 males), all 80 years old, were
investigated in a community-based study. None of the investigated
subjects was being treated for diabetes mellitus and none of the women
had oestrogen replacement. METHODS: Levels of testosterone, oestradiol,
SHBG, IGF-I, GHBP, glucose, insulin and leptin were analysed. Body
composition was measured with bioimpedance analysis (BIA). RESULTS: As
in younger age groups, serum leptin, the ratio leptin/kilogram fat mass
and serum GHBP were higher in the women (all, P< or =0.007), although
serum oestradiol was higher in the men (P<0.001). There were no
significant associations between sex hormones and leptin or GHBP either
in women or in men (all, r<0.13, P>0.1). Leptin correlated to kilogram
fat mass in both women (r=0.55, P<0.001) and men (r=0.47, P=0.003), but
in contrast, there were no significant correlations between GHBP and fat
mass and GHBP and IGF-I, either in women or in men (all, r<0.24, P>0.2).
Insulin and leptin were significantly associated with GHBP, both in
women (r=0.48, P<0.001 and r=0.43, P=0.001, respectively) and in men
(r=0.40, P=0.01 and r=0.34, P=0.03, respectively). CONCLUSIONS: Although
the 80-year-old men had higher oestradiol levels than the women, the
women had higher levels of leptin and GHBP. There were no correlations
between sex hormones and leptin and GHBP, which indicates that the
gender differences are not caused by sex hormones in old age. In
contrast to studies in younger subjects, GHBP did not correlate to fat
mass in the investigated 80-year-old men and women. In the older
subjects investigated, as in younger subjects, GHBP was significantly
correlated with leptin and insulin.
PMID: 14510911 [PubMed - indexed for MEDLINE] |
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