 |
|
| Science Forum Index » Life Extension Forum » Bifidobacterium infantis suppresses IL-17... |
|
Page 1 of 1 |
|
| Author |
Message |
| Kofi... |
 Posted: Tue Nov 17, 2009 9:54 pm |
|
|
|
Guest
|
This might be one of the avenues via which inulin acts as an
antiinflammatory.
Int J Mol Med. 2008 Aug;22(2):181-5.
Bifidobacterium infantis suppresses proinflammatory interleukin-17
production in murine splenocytes and dextran sodium sulfate-induced
intestinal inflammation.
Tanabe S, Kinuta Y, Saito Y.
Graduate School of Biosphere Science, Hiroshima University, Kagamiyama,
Higashi-Hiroshima, Hiroshima, Japan.
Interleukin (IL)-17 acts as a potent inflammatory cytokine, and
IL-17-producing cells (Th17 cells) have received much attention.
However, the involvement of commensal and/or probiotic bacteria in IL-17
production has not been evaluated. In this study, we examined the
suppressive effects of five bacteria species on IL-17 production in
vitro and ex vivo. Among the five species studied, Bifidobacterium
infantis inhibited IL-17 production but enhanced IL-27 production most
potently in TGF-beta plus IL-6-stimulated murine splenocytes. B.
infantis also inhibited IL-17 and eotaxin production from a dextran
sodium sulfate-treated colon organ culture. The induction of IL-10 by B.
infantis was observed both in the splenocytes and in the colon culture
and was assumed, to a certain extent, to be important for suppressing
IL-17 production. These findings suggest a novel immunomodulatory
function of commensal bifidobacteria and further imply that these
bacteria may be useful in the treatment of Th17-mediated diseases.
PMID: 18636171 |
|
|
| Back to top |
|
|
|
|
|
All times are GMT - 5 Hours
The time now is Sat Mar 20, 2010 6:36 am
|
|