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| ironjustice... |
 Posted: Mon Nov 02, 2009 7:47 am |
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Guest
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Antioxidant Treatment With Tempol and Apocynin Prevents
Endothelial Dysfunction and Development of Renovascular
Hypertension.
Costa CA, Amaral TA, Carvalho LC, Ognibene DT, da Silva AF,
Moss MB, Valença SS, de Moura RS, Resende AC
Am J Hypertens 2009 Sep 24.
Background
Two-kidney-one-clip (2K-1C) rats develop renovascular hypertension
associated with endothelial dysfunction and elevated levels of
oxidative
stress.
The role of oxidative damage is unknown in vascular dysfunction
coupled
with 2K-1C hypertension.
The aims of this study were to evaluate the effects of chronic
treatment
with a superoxide dismutase (SOD) mimetic (tempol) and an inhibitor
of
nicotinamide adenine dinucleotide phosphate (NADPH)-dependent
oxidase (apocynin) on the development of hypertension, endothelial
dysfunction, and oxidative damage in 2K-1C rats.
Methods
2K-1C rats and sham-operated rats were treated with tempol or
apocynin
for 40 days, while the corresponding nontreated groups received tap
water.
Blood pressure (BP), mesenteric arterial reactivity, plasma and
mesentery
oxidative damage, mesenteric protein expression, and antioxidant
activities
were compared among the four groups.
Results
Chronic treatment with tempol (1 mmol/l) or apocynin (33 microg/kg/
day)
impaired the development of hypertension in 2K-1C rats and did not
change
the BP in control animals.
The reduction in vasodilatory effect induced by acetylcholine (ACh) in
the
mesenteric arterial beds (MABs) of 2K-1C rats was restored by tempol
and apocynin.
Plasma and mesentery levels of malondialdehyde (MDA) were higher in
2K-1C rats, and these levels were significantly reduced by the
administration
of tempol and apocynin.
Mesenteric SOD activity and expression were higher in 2K-1C rats than
in
the controls, and treatment with tempol resulted in a reduction in SOD
activity.
Conclusions
The data suggest that a compromised mechanism of antioxidant defense
and
an increase in oxidative damage contribute to the development of
hypertension
and associated vascular dysfunction in 2K-1C rats, and that tempol and
apocynin
prevent these effects.
American Journal of Hypertension 2009;
doi:10.1038/ajh.2009.186
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| Marcus Aurelius... |
| Posted: Mon Nov 02, 2009 3:17 pm |
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The main cause of hypertension, with age, is the build up of calcium
within the Aorta resulting in the decrease of distensibility of the
same concomitant with the concomitant increased vascular resistance to
systolic blood flow resulting in greater peripheral vascular
resistance, after load, resulting in "hypertension".This is one of the
main reasons that 25 % of Caucasian men and 50% of black men over the
age of 65 have hypertension. |
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| Ken... |
| Posted: Mon Nov 02, 2009 3:36 pm |
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The time now is Sun Nov 29, 2009 7:21 pm
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