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| ironjustice... |
 Posted: Mon Nov 02, 2009 7:12 am |
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CSF tau protein is a useful marker for effective treatment of
superficial
siderosis of the central nervous system: Two case reports.
Ikeda T, Noto D, Noguchi-Shinohara M, Ono K, Takahashi K, Ishida C,
Yoshita M, Kawaguchi M, Kawahara N, Iwasa K, Tomita K, Yamada M
Clin Neurol Neurosurg 2009 Sep 9.
We report two cases of superficial siderosis (SS) of the central
nervous
system (CNS), which is caused by chronic haemorrhaging into the
subarachnoid space with haemosiderin deposition in the superficial
portion
of the CNS.
Patient 1 had fluid collection in the spinal canal, which was reported
as
the source of the chronic bleeding.
Patient 2 was bleeding from thickened dura at the level of the sacral
vertebrae.
Both of the patients had xanthochromic cerebrospinal fluid.
We surgically repaired the sources of bleeding.
Subsequently the cerebrospinal fluid (CSF) cleared and their symptoms
were not aggravated for about 1 year.
We measured several CSF markers of SS before and after surgery.
Total tau protein (CSF-t-tau), phosphorylated tau protein (CSF-p-
tau),
iron (CSF-iron) and ferritin (CSF-ferritin) in the CSF were highly
elevated
at diagnosis.
After surgery, the levels of CSF-t-tau and CSF-p-tau were markedly
reduced while CSF-iron and CSF-ferritin had not decreased.
It is suggested that CSF-t-tau and CSF-p-tau reflected the neural
damage
in SS and were useful to evaluate the effectiveness of SS therapies.
Clinical neurology and neurosurgery [Clin Neurol Neurosurg]
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| Ken... |
| Posted: Mon Nov 02, 2009 7:19 am |
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