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| Science Forum Index » Life Extension Forum » Topical forskolin protects against UVB carcinogenesis... |
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| Kofi... |
 Posted: Sun Nov 01, 2009 4:10 am |
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Guest
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J Invest Dermatol. 2009 Jan;129(1):162-6. Epub 2008 Jun 26
Forskolin protects keratinocytes from UVB-induced apoptosis and
increases DNA repair independent of its effects on melanogenesis.
Passeron T, Namiki T, Passeron HJ, Le Pape E, Hearing VJ.
Pigment Cell Biology Section, Laboratory of Cell Biology, National
Cancer Institute, National Institutes of Health, Bethesda, Maryland
20892, USA.
Melanin pigments provide efficient protection against ultraviolet B
(UVB) radiation but DNA repair also plays a key role in eliminating
UV-induced damage and preventing the development of skin cancers. In
this study, we demonstrate that forskolin (FSK), an agent that increases
intracellular levels of cAMP, protects keratinocytes from UVB-induced
apoptosis independently from the amount of melanin in the skin. FSK
enhances the removal of the two major types of UVB-induced DNA damage,
cyclobutane pyrimidine dimers and 6,4-photoproducts, by facilitating DNA
repair. These findings suggest new preventive approaches with topical
formulations of FSK or other bioactive agents that could be applied to
the skin before sun exposure to increase its ability to repair DNA
damage.
Publication Types:
* Research Support, N.I.H., Intramural
PMID: 18580960 |
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| Taka... |
| Posted: Sun Nov 01, 2009 5:48 am |
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Guest
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On Nov 1, 6:10 pm, Kofi <k... at (no spam) anon.un> wrote:
[quote] J Invest Dermatol. 2009 Jan;129(1):162-6. Epub 2008 Jun 26
Forskolin protects keratinocytes from UVB-induced apoptosis and
increases DNA repair independent of its effects on melanogenesis.
Passeron T, Namiki T, Passeron HJ, Le Pape E, Hearing VJ.
Pigment Cell Biology Section, Laboratory of Cell Biology, National
Cancer Institute, National Institutes of Health, Bethesda, Maryland
20892, USA.
Melanin pigments provide efficient protection against ultraviolet B
(UVB) radiation but DNA repair also plays a key role in eliminating
UV-induced damage and preventing the development of skin cancers. In
this study, we demonstrate that forskolin (FSK), an agent that increases
intracellular levels of cAMP, protects keratinocytes from UVB-induced
apoptosis independently from the amount of melanin in the skin. FSK
enhances the removal of the two major types of UVB-induced DNA damage,
cyclobutane pyrimidine dimers and 6,4-photoproducts, by facilitating DNA
repair. These findings suggest new preventive approaches with topical
formulations of FSK or other bioactive agents that could be applied to
the skin before sun exposure to increase its ability to repair DNA
damage.
Publication Types:
* Research Support, N.I.H., Intramural
PMID: 18580960
[/quote]
This one is good Kofi, where does this Forskolin come from?
Taka |
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| Ernie... |
| Posted: Sun Nov 01, 2009 11:16 am |
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Guest
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On Nov 1, 1:11 pm, "Ernie" <eprimea... at (no spam) gmail.com> wrote:
[quote]"Taka" <taka0... at (no spam) gmail.com> wrote in message
news:65060fff-ad6b-435b-a192-72ab298d7136 at (no spam) v36g2000yqv.googlegroups.com...
On Nov 1, 6:10 pm, Kofi <k... at (no spam) anon.un> wrote:
J Invest Dermatol. 2009 Jan;129(1):162-6. Epub 2008 Jun 26
Forskolin protects keratinocytes from UVB-induced apoptosis and
increases DNA repair independent of its effects on melanogenesis.
Passeron T, Namiki T, Passeron HJ, Le Pape E, Hearing VJ.
Pigment Cell Biology Section, Laboratory of Cell Biology, National
Cancer Institute, National Institutes of Health, Bethesda, Maryland
20892, USA.
Melanin pigments provide efficient protection against ultraviolet B
(UVB) radiation but DNA repair also plays a key role in eliminating
UV-induced damage and preventing the development of skin cancers. In
this study, we demonstrate that forskolin (FSK), an agent that increases
intracellular levels of cAMP, protects keratinocytes from UVB-induced
apoptosis independently from the amount of melanin in the skin. FSK
enhances the removal of the two major types of UVB-induced DNA damage,
cyclobutane pyrimidine dimers and 6,4-photoproducts, by facilitating DNA
repair. These findings suggest new preventive approaches with topical
formulations of FSK or other bioactive agents that could be applied to
the skin before sun exposure to increase its ability to repair DNA
damage.
Publication Types:
* Research Support, N.I.H., Intramural
PMID: 18580960
This one is good Kofi, where does this Forskolin come from?
Taka
--------
Agreed. It proves my method works. Ernie- Hide quoted text -
- Show quoted text -
[/quote]
asshole babbles using my name due to her inability to convince people
that I am wrong about hair loss, here, or at her www.hairlosshelp.com
snake oil site. Ernie |
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| Ernie... |
| Posted: Sun Nov 01, 2009 1:11 pm |
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Guest
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"Taka" <taka0038 at (no spam) gmail.com> wrote in message
news:65060fff-ad6b-435b-a192-72ab298d7136 at (no spam) v36g2000yqv.googlegroups.com...
On Nov 1, 6:10 pm, Kofi <k... at (no spam) anon.un> wrote:
[quote]J Invest Dermatol. 2009 Jan;129(1):162-6. Epub 2008 Jun 26
Forskolin protects keratinocytes from UVB-induced apoptosis and
increases DNA repair independent of its effects on melanogenesis.
Passeron T, Namiki T, Passeron HJ, Le Pape E, Hearing VJ.
Pigment Cell Biology Section, Laboratory of Cell Biology, National
Cancer Institute, National Institutes of Health, Bethesda, Maryland
20892, USA.
Melanin pigments provide efficient protection against ultraviolet B
(UVB) radiation but DNA repair also plays a key role in eliminating
UV-induced damage and preventing the development of skin cancers. In
this study, we demonstrate that forskolin (FSK), an agent that increases
intracellular levels of cAMP, protects keratinocytes from UVB-induced
apoptosis independently from the amount of melanin in the skin. FSK
enhances the removal of the two major types of UVB-induced DNA damage,
cyclobutane pyrimidine dimers and 6,4-photoproducts, by facilitating DNA
repair. These findings suggest new preventive approaches with topical
formulations of FSK or other bioactive agents that could be applied to
the skin before sun exposure to increase its ability to repair DNA
damage.
Publication Types:
* Research Support, N.I.H., Intramural
PMID: 18580960
[/quote]
This one is good Kofi, where does this Forskolin come from?
Taka
--------
Agreed. It proves my method works. Ernie |
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| Ernie... |
| Posted: Sun Nov 01, 2009 4:17 pm |
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Guest
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On Nov 1, 6:07 pm, Live from the Engine Room <davidp... at (no spam) yahoo.com>
wrote:
[quote]Ernie wrote:
"Ernie" <eprimea... at (no spam) gmail.com> wrote:
"Taka" <taka0... at (no spam) gmail.com> wrote in message
news:65060fff-ad6b-435b-a192-72ab298d7136 at (no spam) v36g2000yqv.googlegroups.com....
On Nov 1, 6:10 pm, Kofi <k... at (no spam) anon.un> wrote:
J Invest Dermatol. 2009 Jan;129(1):162-6. Epub 2008 Jun 26
Forskolin protects keratinocytes from UVB-induced apoptosis and
increases DNA repair independent of its effects on melanogenesis.
Passeron T, Namiki T, Passeron HJ, Le Pape E, Hearing VJ.
Pigment Cell Biology Section, Laboratory of Cell Biology, National
Cancer Institute, National Institutes of Health, Bethesda, Maryland
20892, USA.
Melanin pigments provide efficient protection against ultraviolet B
(UVB) radiation but DNA repair also plays a key role in eliminating
UV-induced damage and preventing the development of skin cancers. In
this study, we demonstrate that forskolin (FSK), an agent that increases
intracellular levels of cAMP, protects keratinocytes from UVB-induced
apoptosis independently from the amount of melanin in the skin. FSK
enhances the removal of the two major types of UVB-induced DNA damage,
cyclobutane pyrimidine dimers and 6,4-photoproducts, by facilitating DNA
repair. These findings suggest new preventive approaches with topical
formulations of FSK or other bioactive agents that could be applied to
the skin before sun exposure to increase its ability to repair DNA
damage.
Publication Types:
* Research Support, N.I.H., Intramural
PMID: 18580960
This one is good Kofi, where does this Forskolin come from?
Taka
--------
Agreed. It proves my method works. Ernie- Hide quoted text -
asshole babbles using my name due to her inability to convince people
that I am wrong about hair loss, here, or at herwww.hairlosshelp.com
snake oil site. Ernie
Ernie69 may be believed about that if she could show us "one lasting
hair" on her bald scalp, but she has repeatedly refused to post recent
pictures of herself.- Hide quoted text -
- Show quoted text -
[/quote]
As far as we know, the old pussy asshole farrel is the only she here
with a clit. Ernie |
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| Live from the Engine Room... |
| Posted: Sun Nov 01, 2009 6:07 pm |
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Guest
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Ernie wrote:
[quote]"Ernie" <eprimea... at (no spam) gmail.com> wrote:
"Taka" <taka0... at (no spam) gmail.com> wrote in message
news:65060fff-ad6b-435b-a192-72ab298d7136 at (no spam) v36g2000yqv.googlegroups.com...
On Nov 1, 6:10 pm, Kofi <k... at (no spam) anon.un> wrote:
J Invest Dermatol. 2009 Jan;129(1):162-6. Epub 2008 Jun 26
Forskolin protects keratinocytes from UVB-induced apoptosis and
increases DNA repair independent of its effects on melanogenesis.
Passeron T, Namiki T, Passeron HJ, Le Pape E, Hearing VJ.
Pigment Cell Biology Section, Laboratory of Cell Biology, National
Cancer Institute, National Institutes of Health, Bethesda, Maryland
20892, USA.
Melanin pigments provide efficient protection against ultraviolet B
(UVB) radiation but DNA repair also plays a key role in eliminating
UV-induced damage and preventing the development of skin cancers. In
this study, we demonstrate that forskolin (FSK), an agent that increases
intracellular levels of cAMP, protects keratinocytes from UVB-induced
apoptosis independently from the amount of melanin in the skin. FSK
enhances the removal of the two major types of UVB-induced DNA damage,
cyclobutane pyrimidine dimers and 6,4-photoproducts, by facilitating DNA
repair. These findings suggest new preventive approaches with topical
formulations of FSK or other bioactive agents that could be applied to
the skin before sun exposure to increase its ability to repair DNA
damage.
Publication Types:
* Research Support, N.I.H., Intramural
PMID: 18580960
This one is good Kofi, where does this Forskolin come from?
Taka
--------
Agreed. It proves my method works. Ernie- Hide quoted text -
asshole babbles using my name due to her inability to convince people
that I am wrong about hair loss, here, or at her www.hairlosshelp.com
snake oil site. Ernie
[/quote]
Ernie69 may be believed about that if she could show us "one lasting
hair" on her bald scalp, but she has repeatedly refused to post recent
pictures of herself. |
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| Kofi... |
| Posted: Mon Nov 02, 2009 4:03 am |
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Guest
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[quote]Publication Types:
* Research Support, N.I.H., Intramural
PMID: 18580960
This one is good Kofi, where does this Forskolin come from?
[/quote]
Beyond-a-Century carries it. |
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| gedropi... |
| Posted: Mon Nov 02, 2009 6:43 am |
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Guest
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On Nov 2, 1:03 am, Kofi <k... at (no spam) anon.un> wrote:
[quote]Publication Types:
* Research Support, N.I.H., Intramural
PMID: 18580960
This one is good Kofi, where does this Forskolin come from?
Beyond-a-Century carries it.
[/quote]
It comes from the coleus plant, as well. |
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