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FASEB J. 2008 May;22(5):1502-11. Epub 2008 Jan 2.
A novel adipokine CTRP1 stimulates aldosterone production.
Jeon JH, Kim KY, Kim JH, Baek A, Cho H, Lee YH, Kim JW, Kim D, Han SH,
Lim JS, Kim KI, Yoon do Y, Kim SH, Oh GT, Kim E, Yang Y.
Department of Life Science, Sookmyung Women's University, Seoul 140-742,
Korea.
Complement-C1q TNF-related protein 1 (CTRP1), a member of the CTRP
superfamily, is expressed at high levels in adipose tissues of obese
Zucker diabetic fatty (fa/fa) rats, and CTRP1 expression is induced by
proinflammatory cytokines, including TNF-alpha and IL-1beta. In the
present study, we investigated stimulation of aldosterone production by
CTRP1, since it was observed that CTRP1 was specifically expressed in
the zona glomerulosa of the adrenal cortex, where aldosterone is
produced. Increased aldosterone production by CTRP1 in cells of the
human adrenal cortical cell line H295R was dose-dependent. Expression
levels of aldosterone synthase CYP11B2 were examined to investigate the
molecular mechanisms by which CTRP1 enhances the production of
aldosterone. The expression of CYP11B2 was greatly increased by
treatment with CTRP1, as was the expression of the transcription factors
NGFIB and NURR1, which play critical roles in stimulation of CYP11B2
gene expression. It was also revealed that angiotensin II-induced
aldosterone production is, at least in part, mediated by the stimulation
of CTRP1 secretion, not by the increase of CTRP1 mRNA transcription. In
addition, the levels of CTRP1 were significantly up-regulated in
hypertensive patients' serum. As CTRP1 was highly expressed in obese
subjects as well as up-regulated in hypertensive patients, CTRP1 may be
a newly identified molecular link between obesity and hypertension.
Publication Types:
* Research Support, Non-U.S. Gov't
PMID: 18171693 |
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