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 Posted: Sat Oct 31, 2009 5:24 pm |
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Ann N Y Acad Sci. 2009 Aug;1171:377-84.
A ketogenic diet increases succinic dehydrogenase activity in aging
cardiomyocytes.
Balietti M, Fattoretti P, Giorgetti B, Casoli T, Di Stefano G, Solazzi
M, Platano D, Aicardi G, Bertoni-Freddari C.
Neurobiology of Aging Laboratory, Italian National Research Centers on
Aging, Ancona, Italy.
Impairment of energy metabolism and an increase of reactive oxygen
species (ROS) production seem to play a major role in age-related
apoptotic loss of cardiomyocytes. Succinic dehydrogenase (SDH) is an
important marker of the mitochondrial capability to provide an adequate
amount of ATP. Moreover, because of its unique redox properties, SDH
activity contributes to maintain the reduced state of the ubiquinone
pool. Recent reports have shown that ketone body intake improves cardiac
metabolic efficiency and exerts a cardioprotective antioxidant action,
we therefore performed a cytochemical investigation of SDH activity in
cardiomyocytes of late-adult (19-month-old) rats fed for 8 weeks with a
medium-chain triglycerides ketogenic diet (MCT-KD). Young, age-matched
and old animals fed with a standard chow were used as controls. The
overall area of the precipitates (PA) from SDH activity and the area of
the SDH-positive mitochondria (MA) were measured. The percent ratios
PA/MA and MA/total myocardial tissue area (MA/TA) were the parameters
taken into account. We found that PA/MA was significantly higher in
young control rats and in MCT-KD-fed rats versus late-adult and old
control rats and in young control versus MCT-KD-fed rats. MA/TA of
MCT-KD-fed rats was significantly higher versus age-matched and old
control rats and tended to be higher versus young control rats; this
parameter was significantly higher in young versus old control rats.
Thus, MCT-KD intake partially recovers age-related decrease of SDH
activity and increases the myocardial area occupied by metabolically
active mitochondria. These effects might counteract metabolic
alterations leading to apoptosis-induced myocardial atrophy and failure
during aging.
PMID: 19723079 |
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