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 Posted: Wed Oct 28, 2009 11:17 am |
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http://www.ncbi.nlm.nih.gov/pubmed/19781131
Br J Nutr. 2009 Sep 28:1-7. [Epub ahead of print]
Vitamin D supplementation reduces insulin resistance in South Asian
women living in New Zealand who are insulin resistant and vitamin D
deficient - a randomised, placebo-controlled trial.
von Hurst PR, Stonehouse W, Coad J.
Institute of Food, Nutrition and Human Health, Massey University,
Private Bag 102 904, North Shore Mail Centre, Auckland, New Zealand.
Low serum 25-hydroxyvitamin D (25(OH)D) has been shown to correlate
with increased risk of type 2 diabetes. Small, observational studies
suggest an action for vitamin D in improving insulin sensitivity
and/or insulin secretion. The objective of the present study was to
investigate the effect of improved vitamin D status on insulin
resistance (IR), utilising randomised, controlled, double-blind
intervention administering 100 mug (4000 IU) vitamin D3 (n 42) or
placebo (n 39) daily for 6 months to South Asian women, aged 23-68
years, living in Auckland, New Zealand. Subjects were insulin
resistant - homeostasis model assessment 1 (HOMA1)>1.93 and had serum
25(OH)D concentration < 50 nmol/l. Exclusion criteria included
diabetes medication and vitamin D supplementation >25 mug (1000 IU)/d.
The HOMA2 computer model was used to calculate outcomes. Median (25th,
75th percentiles) serum 25(OH)D3 increased significantly from 21 (11,
40) to 75 (55, 84) nmol/l with supplementation. Significant
improvements were seen in insulin sensitivity and IR (P = 0.003 and
0.02, respectively), and fasting insulin decreased (P = 0.02) with
supplementation compared with placebo. There was no change in C-
peptide with supplementation. IR was most improved when endpoint serum
25(OH)D reached >/= 80 nmol/l. Secondary outcome variables (lipid
profile and high sensitivity C-reactive protein) were not affected by
supplementation. In conclusion, improving vitamin D status in insulin
resistant women resulted in improved IR and sensitivity, but no change
in insulin secretion. Optimal vitamin D concentrations for reducing IR
were shown to be 80-119 nmol/l, providing further evidence for an
increase in the recommended adequate levels. Registered Trial No.
ACTRN12607000642482.
PMID: 19781131 [PubMed - as supplied by publisher] |
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