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| Science Forum Index » Medicine - Nutrition Forum » Shellfish gives you diabetes... |
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| Taka... |
 Posted: Fri Oct 23, 2009 2:45 am |
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"Interestingly, the researchers found that eating shellfish at least
once per week was associated with a 36% increased risk for Type 2
diabetes, which they suggest may be related to cooking methods and
condiments as shellfish tend to be fried and accompanied by mayonnaise
or garlic butter."
SOURCE: http://www.lipidsonline.org/news/article.cfm?aid=8473
"Fried fish was not significantly associated with diabetes risk.
Consuming one or more portions/week of shellfish was associated with
an increased risk of diabetes"
SOURCE: http://care.diabetesjournals.org/content/32/10/1857
"These findings do not support the use of low-fat diets to prevent
weight gain"
PMID: 19828709
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You know the drill, oily fish is all good but once you turn it into
shellfish ...
Taka |
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| montygraham... |
| Posted: Fri Oct 23, 2009 6:21 pm |
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I've known a couple of people for a very long time who can't eat
shellfish. They get severe pain, and gallstones seem to run in their
family (doctors told them this was likely the "connection"). In any
case, of course one has to control for the other potentially causative
factors. However, the evidence suggests that there are unique
properties to the "cholesterol" in shellfish that may be causing major
problems (in the bodies of people who consume a lot of it). For
example:
The acyl-CoA: cholesterol acyl transferase (ACAT) reaction in
macrophages is a critical step in atherosclerotic foam cell formation,
but little is known about the reaction's sterol substrate specificity.
In this report we examine the macrophage ACAT reactivity of the
shellfish sterol, desmosterol, and other sterols found in man because
of shellfish ingestion or in association with the foam cell diseases
sitosterolemia and cerebrotendinous xanthomatosis (CTX). We first show
that the J774 macrophage, a foam cell model with a hyperactive ACAT
pathway, synthesizes desmosterol instead of cholesterol and that both
endogenous and exogenous desmosterol are substrates and stimulators of
the ACAT reaction in these cells. When exogenous desmosterol was added
to human monocyte-derived macrophages, ACAT was stimulated 29- and 4-
fold compared with control and cholesterol-treated cells,
respectively. Steryl ester mass accumulation in desmosterol-treated
human macrophages was 10-fold greater than in control cells and 3-fold
greater than in cholesterol-treated cells. Another shellfish sterol,
24-methylene cholesterol, also stimulated ACAT in human macrophages,
but most of the xanthomatosis-related sterols did not stimulate ACAT.
These data suggest that: (a) the shellfish sterols desmosterol and 24-
methylene cholesterol may be atherogenic; and (b) the excessive foam
cell formation seen in sitosterolemia and CTX cannot be explained by
ACAT hyperreactivity of their associated sterols.
Source: J. Clin. Invest. 84(6): 1713-1721 (1989).
Online: http://www.jci.org/articles/view/114354 |
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