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| trigonometry1972 at (no spam) gmail.com |... |
 Posted: Sun Oct 11, 2009 11:14 pm |
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Guest
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Remember the EU want to refuse gamma tocopherol
in supplements.
J Nutr Biochem. 2008 Nov 5. [Epub ahead of print]
A combination of aspirin and gamma-tocopherol is superior to that of
aspirin and alpha-tocopherol in anti-inflammatory action and
attenuation of aspirin-induced adverse effects.
Jiang Q, Moreland M, Ames BN, Yin X.
Department of Foods and Nutrition,
Interdepartmental Nutrition Program, Purdue
University, West Lafayette, IN 47907, USA.
Nonsteroidal anti-inflammatory drugs such as aspirin are used for pain
relief and chemoprevention against cancer, but frequently cause
gastric mucosal injury. We examined whether combinations of aspirin
and alpha-tocopherol (alphaT) or aspirin and gamma-tocopherol
(gammaT), with alphaT and gammaT being the two major forms of vitamin
E, are better anti-inflammatory agents than aspirin alone, and whether
these combinations alleviate aspirin-associated side effects. In the
carrageenan-induced air-pouch inflammation model in the rat, aspirin
(150 mg/kg) or a combination of aspirin and gammaT (33 mg/kg)
inhibited proinflammatory prostaglandin E(2) (PGE(2)) by 70% (P<.02)
at the inflammation site 6 h after inflammation was initiated.
However, at 18 h, only the combination decreased exudate volume (15%;
P<.05) and showed modest inhibition of PGE(2) (40%; P<.07) and lactate
dehydrogenase activity (30%; P=.07) in the fluid collected at the
inflammation site. gammaT, but not alphaT, spared aspirin-induced
reduction in
food intake, partially reversed aspirin-depressed gastric PGE(2) and
attenuated stomach lesions. Surprisingly, the combination of aspirin
and alphaT (33 mg/kg) did not show more benefits than aspirin alone,
but worsened gastric injury and food intake reduction. Our study
demonstrated that a combination of aspirin and gammaT, but not a
combination of aspirin and alphaT, has some advantage over aspirin
alone in terms of anti-inflammatory effects and attenuation of aspirin-
induced adverse effects. This combination may be useful in
complementing aspirin in the treatment of chronic inflammatory
conditions and cancer.
PMID: 18993050 |
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| vauxall... |
| Posted: Mon Oct 12, 2009 6:14 am |
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x-no-archive:yes
On Oct 12, 10:14 am, "trigonometry1... at (no spam) gmail.com |"
<trigonometry1... at (no spam) gmail.com> wrote:
[quote:8227efc510]Remember the EU want to refuse gamma tocopherol
in supplements.
[/quote:8227efc510]
OMG, what is the motivation? |
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| trigonometry1972 at (no spam) gmail.com |... |
| Posted: Fri Oct 16, 2009 4:11 pm |
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On Oct 16, 4:21 pm, RF <R... at (no spam) NoDen.con> wrote:
[quote:ca09fe2063]vauxall wrote:
x-no-archive:yes
On Oct 12, 10:14 am, "trigonometry1... at (no spam) gmail.com |"
trigonometry1... at (no spam) gmail.com> wrote:
Remember the EU want to refuse gamma tocopherol
in supplements.
OMG, what is the motivation?
Curiously DrWeil appears to think that a mixture of alpha to delta
tocopherals AND tocotrienols is the right form to use.
[/quote:ca09fe2063]
And he is likely right. I know I want gamma tocopherol in
the mix. And I still think tocotrienol look useful though
I don't plan to take 1000 mg doses tocotrienols.
The tocotrienols look very potent and they
seem to stress the liver. So for now I'll keep
my dose of the latter at or below about 200 mgs.
And I avoid the racemic form aka dl alpha tocopherol.
Trig |
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| RF... |
| Posted: Fri Oct 16, 2009 5:21 pm |
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vauxall wrote:
[quote:bf52bd3708]x-no-archive:yes
On Oct 12, 10:14 am, "trigonometry1... at (no spam) gmail.com |"
trigonometry1... at (no spam) gmail.com> wrote:
Remember the EU want to refuse gamma tocopherol
in supplements.
OMG, what is the motivation?
[/quote:bf52bd3708]
Curiously DrWeil appears to think that a mixture of alpha to delta
tocopherals AND tocotrienols is the right form to use. |
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| Mark Thorson... |
| Posted: Sat Oct 17, 2009 9:59 am |
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"trigonometry1972 at (no spam) gmail.com |" wrote:
[quote:9c740bf6cd]
And he is likely right. I know I want gamma tocopherol in
the mix. And I still think tocotrienol look useful though
I don't plan to take 1000 mg doses tocotrienols.
The tocotrienols look very potent and they
seem to stress the liver. So for now I'll keep
my dose of the latter at or below about 200 mgs.
[/quote:9c740bf6cd]
If you wanted to be safe, you'd apply a factor of 10
below the no observable adverse effects level (NOAEL)
in humans, and then another factor of 10 if the data
is from another animal, because an animal model can be
less sensitive than a human model. At least, that's
the methodology often used to set maximum dosages. |
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| trigonometry1972 at (no spam) gmail.com |... |
| Posted: Sun Oct 18, 2009 2:41 am |
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Guest
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On Oct 17, 8:59 am, Mark Thorson <nos... at (no spam) sonic.net> wrote:
[quote:e2b26b2027]"trigonometry1... at (no spam) gmail.com |" wrote:
And he is likely right. I know I want gamma tocopherol in
the mix. And I still think tocotrienol look useful though
I don't plan to take 1000 mg doses tocotrienols.
The tocotrienols look very potent and they
seem to stress the liver. So for now I'll keep
my dose of the latter at or below about 200 mgs.
If you wanted to be safe, you'd apply a factor of 10
below the no observable adverse effects level (NOAEL)
in humans, and then another factor of 10 if the data
is from another animal, because an animal model can be
less sensitive than a human model. At least, that's
the methodology often used to set maximum dosages.
[/quote:e2b26b2027]
Pretty close to 30 mgs maybe 20 mg. Doses around
200 milligrams have been used rather widely and
in at least one relatively long human based study.
A dose around 50 mgs starts to lower
cholesterol levels as I recall.
A factor of 10 safety factor type thinking is
the cause of 80 or 90 percent of the type one
diabetes in the population. It is an unsound
methodology in application. That this rule of
thumb it has been used doesn't mean it isn't
suspect or that it doesn't have "blood
on its hands." |
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