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Science Forum Index » Medicine - Nutrition Forum » Major depression and LC-PUFA seasonal variation:...
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 Posted: Tue Jul 01, 2008 7:29 pm |
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" Investigators have described the seasonality of depression and
suicide, with more deaths in spring and summer vs. autumn and winter.
Total serum cholesterol has been highly significantly synchronized
with the annual rhythms in violent suicide deaths. Recently,
investigators found that EFA levels also vary by season, with peaks of
EPA and DHA from August to September. The parent omega-3 and 6 levels
did not have a seasonal variation, suggesting a seasonal interference
with delta-5-desaturase conversion. The authors of this study suggest
that the seasonal variation in EPA or DHA may partially explain
seasonality of violent suicide occurrence."
SOURCE:
http://www.lipidworld.com/content/3/1/25
http://www.innovitaresearch.org/news/05010701.html
Prostaglandins Leukot Essent Fatty Acids. 2004 Jul;71(1):13-8.
In humans, the seasonal variation in poly-unsaturated fatty acids is
related to the seasonal variation in violent suicide and serotonergic
markers of violent suicide.
De Vriese SR, Christophe AB, Maes M.
Department of Internal Medicine, Division of Nutrition, Ghent
University Hospital, Belgium.
BACKGROUND: Depression is accompanied by a depletion of n-3 poly-
unsaturated fatty acids (PUFAs). There is also a negative correlation
between suicide and fish-oil intake (rich in n-3 PUFAs) across
different countries. Both depression and suicide show a seasonal
variation and are related to disorders in the serotonergic system.
AIMS: The present study was carried out to determine if there is a
seasonal variation in the PUFA fractions in serum phospholipids and
whether there are significant relationships between lowered n-3 PUFA
status and the seasonal variation in the number of suicide deaths and
serotonergic markers of suicide. METHODS: We took monthly blood
samples during 1 calendar year from 23 healthy volunteers and analyzed
the PUFA composition in serum phospholipids and related those data to
the annual variation in the mean weekly number of suicides for Belgium
and the Bmax [3H]-paroxetine binding to platelets in the same 23
subjects. RESULTS: Significant annual rhythms were detected in the
long-chain PUFAs only, i.e. arachidonic acid (C20: 4n-6; AA),
eicosapentaenoic acid (C20: 5n-3; EPA), and docosahexaenoic acid (C22:
6n-3; DHA). There was a significant correlation between the changes
over the last 2 weeks in AA and EPA and the mean weekly number of
violent, but not nonviolent, suicide deaths in Belgium. There was a
significant correlation between the PUFAs, AA and DHA, and the Bmax
[3H]-paroxetine binding to platelets. CONCLUSIONS: Our results show
that there is a true seasonality in long-chain PUFAs, such as AA, EPA
and DHA. The results suggest that the seasonality in PUFAs may be
related to the incidence of violent suicide and the expression of the
serotonin transporter complex. Copyright 2004 Elsevier Ltd.
PMID: 15172679
Psychosom Med. 2007 Dec;69(9):932-4. Epub 2007 Nov 8.
High omega-6 and low omega-3 fatty acids are associated with
depressive symptoms and neuroticism.
Conklin SM, Manuck SB, Yao JK, Flory JD, Hibbeln JR, Muldoon MF.
Department of Psychology, Allegheny College, 520 North Main Street,
Meadville, PA 16335-3902, USA.
OBJECTIVE: To examine the concentrations of omega-3 and omega-6
polyunsaturated fatty acids in serum obtained from nonpatient
community volunteers not selected for hypercholesterolemia. Previously
we reported that the relative concentrations of omega-3 and omega-6
polyunsaturated fatty acids in serum covary with depressive
symptomatology and neuroticism in hypercholesterolemic adults.
METHODS: A total of 116 adults without current Axis I psychopathology
completed the Beck Depression Inventory (BDI) and the NEO Personality
Inventory--Revised (NEO-PI-R). Fasting serum phospholipid
eicosapentaenoic (EPA), docosahexaenoic (DHA), and arachidonic acid
(AA) were determined (% of total pool). RESULTS: Higher AA and AA:EPA
ratio, adjusted for age, gender, and race, were associated with
greater depressive symptomatology (BDI score of >or=10). Lower EPA,
and higher AA, AA:EPA ratio and AA:DHA ratio were associated with
greater NEO-PI-R Neuroticism. The six Neuroticism subscales were each
associated with two or more fatty acid measurements. CONCLUSIONS: In
conjunction with other reports, these findings suggest that the
omega-3 and omega-6 fatty acids are related to negative affect at both
the symptom and trait levels.
PMID: 17991818 |
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