Wake up and smell the coffee: Study finds that caffeine may help
prevent MS
A good cup of coffee might be just the wake-up call scientists need to
stop multiple sclerosis.

A new study coauthored by Oklahoma Medical Research Foundation
scientist Linda Thompson, Ph.D., found that mice immunized to develop
an MS-like condition were protected from the disease by drinking
caffeine. The research appears in the early online edition of the June
30, 2008 Proceedings of the National Academy of Sciences.

In the study, done in collaboration with Cornell University and
Finland's University of Turku, researchers followed the progress of
mice that normally developed an MS-like condition. The scientists
discovered that when the rodents consumed the equivalent of six to
eight cups of coffee a day, they did not develop the condition. The
finding could lead to new ways to prevent and treat MS, said
Thompson.

According to Thompson, the caffeine stopped adenosine (one of the four
building blocks in DNA) from binding to an adenosine receptor in mice.
Adenosine is a common molecule in the human body and plays a vital
part in the biochemical processes of sleep, suppression of arousal and
energy transfer.

When adenosine could not bind to the receptor, this prevented certain
T cells—white blood cells that play a central role in immune responses—
from reaching the central nervous system and triggering the cascade of
events that lead to experimental autoimmune encephalomyelitis, or EAE,
the animal model for the human disease MS.

"This is an exciting and unexpected finding, and I think it could be
important for the study of MS and other diseases," said Thompson, who
holds the Putnam City Schools Distinguished Chair in Cancer Research
at OMRF. In particular, she said, the research holds potential for
lupus, rheumatoid arthritis and other autoimmune diseases—conditions
in which the body uses the weapons of its immune system against
itself.
While the results are heartening, Thompson said there is much more
work to be done for the prevention of multiple sclerosis in humans. "A
mouse is not a human being, so we can't be sure caffeine will have the
same effect on people prone to develop MS without much more testing."

A retrospective study of people with MS to track their caffeine intake
and the effects on the disease could be an important next step in the
research process, said Thompson. "If you found a correlation between
caffeine intake and reduced MS symptoms, that would point to further
studies in humans."

MS is disorder of the central nervous system marked by weakness,
numbness, a loss of muscle coordination, and problems with vision,
speech and bladder control. Believed to be an autoimmune disease in
which the body's immune system attacks nerves in the brain and spinal
cord, MS affects approximately 400,000 Americans and 2.5 million
people worldwide.

Source: Oklahoma Medical Research Foundation

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Tom

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On Jun 30, 5:27 pm, ironjustice <teamtan... at (no spam) hotmail.com> wrote:
caffeine may help
 prevent MS

"Theophylline"

Theophylline is used to lower red blood cell count .. and
caffiene .. ?

Titre du document / Document title
Determination of adenine, caffeine, theophylline and theobromine by
HPLC with amperometric detection
Auteur(s) / Author(s)
MEYER A. (1) ; NGIRUWONSANGA T. (1) ; HENZE G. (1) ;
Affiliation(s) du ou des auteurs / Author(s) Affiliation(s)
(1) Fachbereich Chemie der Universität Kaiserlautern und Abteilung für
Anorganische und Analytische Chemie der Universität Trier, Postfach
3825, 54228 Trier, ALLEMAGNE

Résumé / Abstract
A relatively simple method for quantifying caffeine, theobromine,
theophylline and adenine by HPLC with amperometric detection was
developed. A C18-column and an isocratic elution with phosphate buffer
pH 3.5/methanol (90 :10) were employed for the chromatographic
separation of the investigated compounds. The optimal detection
potential was +1.4 V. The limits of detection were 0.4 ng for adenine,
1 ng for theophylline and 2.5 ng for caffeine and theobromine. The
method was applied to the determination of these purine alkaloids in
beverages, tea, coffee and cacao. The determination was carried out
directly or after solid-phase extraction.
Revue / Journal Title
Fresenius' journal of analytical chemistry   ISSN 0937-0633
Source / Source
Congrès
ELACH Meeting No2, Clausthal-Zellerfeld , ALLEMAGNE (02/10/1995)
1996, vol. 356, no 3-4 (154 p.)  (28 ref.), pp. 284-287
Langue / Language
Anglais

Editeur / Publisher
Springer, Berlin, ALLEMAGNE (1990-2001) (Revue)

Mots-clés anglais / English Keywords
Chemical analysis ; Alkaloid ; Caffeine ; Adenine ; Theophyllin ;
Theobromine ; Xanthine derivatives ; Stimulative beverage ; Tea ;
Coffee ; Cola beverage ; Cocoa ; Food products ; Solid phase
extraction ; Trace analysis ; High performance liquid chromatography ;
Electrochemical detector ; Amperometry ;
Mots-clés français / French Keywords
Analyse chimique ; Alcaloïde ; Caféine ; Adénine ; Théophylline ;
Théobromine ; Xanthine dérivé ; Boisson stimulante ; Thé ; Café ;
Boisson de cola ; Cacao ; Produit alimentaire ; Extraction SPE ;
Analyse trace ; Chromatographie HPLC ; Détecteur électrochimique ;
Ampérométrie ;
Mots-clés espagnols / Spanish Keywords
Alcaloide ; Adenina ; Xantina derivado ; Bebida estimulante ; Té ;
Café ; Bebida cola ; Cacao ; Extracción SPE ; Detector
electroquímico ; Amperometría ;
Localisation / Location
INIST-CNRS, Cote INIST : 853, 35400006628698.0260

Copyright 2007 INIST-CNRS. All rights reserved

Toute reproduction ou diffusion même partielle, par quelque procédé ou
sur tout support que ce soit, ne pourra être faite sans l'accord
préalable écrit de l'INIST-CNRS.
No part of these records may be reproduced of distributed, in any form
or by any means, without the prior written permission of INIST-CNRS.

Nº notice refdoc (ud4) : 3232470

Who loves ya.
Tom

Jesus Was A Vegetarian!http://tinyurl.com/2r2nkh

Man Is A Herbivore!http://tinyurl.com/4rq595

DEAD PEOPLE WALKINGhttp://tinyurl.com/zk9fk



Wake up and smell the coffee: Study finds that caffeine may help
prevent MS
A good cup of coffee might be just the wake-up call scientists need to
stop multiple sclerosis.

A new study coauthored by Oklahoma Medical Research Foundation
scientist Linda Thompson, Ph.D., found that mice immunized to develop
an MS-like condition were protected from the disease by drinking
caffeine. The research appears in the early online edition of the June
30, 2008 Proceedings of the National Academy of Sciences.

In the study, done in collaboration with Cornell University and
Finland's University of Turku, researchers followed the progress of
mice that normally developed an MS-like condition. The scientists
discovered that when the rodents consumed the equivalent of six to
eight cups of coffee a day, they did not develop the condition. The
finding could lead to new ways to prevent and treat MS, said
Thompson.

According to Thompson, the caffeine stopped adenosine (one of the four
building blocks in DNA) from binding to an adenosine receptor in mice.
Adenosine is a common molecule in the human body and plays a vital
part in the biochemical processes of sleep, suppression of arousal and
energy transfer.

When adenosine could not bind to the receptor, this prevented certain
T cells—white blood cells that play a central role in immune responses—
from reaching the central nervous system and triggering the cascade of
events that lead to experimental autoimmune encephalomyelitis, or EAE,
the animal model for the human disease MS.

"This is an exciting and unexpected finding, and I think it could be
important for the study of MS and other diseases," said Thompson, who
holds the Putnam City Schools Distinguished Chair in Cancer Research
at OMRF. In particular, she said, the research holds potential for
lupus, rheumatoid arthritis and other autoimmune diseases—conditions
in which the body uses the weapons of its immune system against
itself.
While the results are heartening, Thompson said there is much more
work to be done for the prevention of multiple sclerosis in humans. "A
mouse is not a human being, so we can't be sure caffeine will have the
same effect on people prone to develop MS without much more testing."

A retrospective study of people with MS to track their caffeine intake
and the effects on the disease could be an important next step in the
research process, said Thompson. "If you found a correlation between
caffeine intake and reduced MS symptoms, that would point to further
studies in humans."

MS is disorder of the central nervous system marked by weakness,
numbness, a loss of muscle coordination, and problems with vision,
speech and bladder control. Believed to be an autoimmune disease in
which the body's immune system attacks nerves in the brain and spinal
cord, MS affects approximately 400,000 Americans and 2.5 million
people worldwide.

Source: Oklahoma Medical Research Foundation

Who loves ya.
Tom

Jesus Was A Vegetarian!http://tinyurl.com/2r2nkh

Man Is A Herbivore!http://tinyurl.com/4rq595

DEAD PEOPLE WALKINGhttp://tinyurl.com/zk9fk- Hide quoted text -

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