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Science Forum Index » Medicine - Nutrition Forum » ffect of quercetin, flavonoids and alpha-tocopherol,...
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| trigonometry1972 at (no spam) gmail.com |... |
 Posted: Tue Jun 24, 2008 5:05 pm |
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Guest
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Abstract below and my comments are above.
Thankfully I can still purchase quercetin and rutin.
I take it in a regular basis and have for some years
at larger doses. I suspect this is another thing
that keep me in remission from GERD in addition to the
betaine HCL and melatonin plus my use
of an inclined sleep position when needed.
Eur J Pharmacol. 2008 May 7. [Epub ahead of print]
Effect of quercetin,
flavonoids and alpha-tocopherol,
an antioxidant vitamin on experimental reflux
oesophagitis in rats.
Rao CV, Vijayakumar M.
Gastropharmacology laboratory,
Pharmacognosy and Ethnopharmacology Division,
National Botanical Research Institute,
Rana Partap Marg, Lucknow 226 001,
Uttar Pradesh, India.
Protective effect of quercetin and alpha-tocopherol
on experimental reflux oesophagitis in rats was investigated.
Rats received quercetin, (100 mg/kg), alpha-tocopherol (16 mg/kg),
omeprazole (30 mg/kg) given at 1 h prior to surgery.
Quercetin and alpha-tocopherol significantly inhibited
the oesophagitis index to 1.33+/-0.12 (P<0.001)
and 1.83+/-0.14 (P<0.001) respectively, as compare to
control group 3.5+/-0.21. Further, acid and pepsin out
put of gastric contents were significantly decreased
in treated groups. Indeed, quercetin significantly
inhibited the lipid peroxidation (from 0.69+/-0.05
to 0.43+/-0.04 nmol of malonyldialdehyde (MDA)/mg protein)
(P<0.001) and increased in levels of catalase
to 29.5+/-2.7 units of catalase activity/mg protein
and superoxide dismutase (SOD) to 92.4+/-10.5
units/mg protein (P<0.001). The alpha-tocopherol and
omperazole showed significant inhibition in lipid
peroxidation (0.34+/-0.02 and 0.38+/-0.01) (P<0.01)
and enhanced the activities of catalase (34.3+/-3.6 and
31.5+/-3.4) (P<0.01) and SOD (87.3+/-9.2 and 76.60+/-6.9)
activity. Quercetin and alpha-tocopherol treated
group significantly increased the glutathione level to
36.5+/-2.78 (P<0.01) and 32.1+/-2.34 (P<0.05)
respectively. However, it altered the elevated
levels of sialic acid and hexose contents in
oesophageal tissue. Indeed, quercetin significantly
decreased the elevated plasma histamine content
(P<0.05). Quercetin and alpha-tocopherol significantly
attenuated the elevated level of collagen in
oesophageal tissue as of the omeprazole.
The results suggest that antioxidants
could attenuate the severity of reflux
oesophagitis and prevent the oesophageal mucosal
damage and validate its therapeutic use in
gastroesophageal reflux disease.
PMID: 18547560 |
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