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Science Forum Index » Life Extension Forum » Comparison of metabolic rate and oxidative stress...
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 Posted: Wed Jun 11, 2008 10:16 am |
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Exp Gerontol. 2008 May 4. [Epub ahead of print]
Ferguson M, Rebrin I, Forster MJ, Sohal RS.
Department of Pharmacology and Pharmaceutical Sciences, University of
Southern California, 1985 Zonal Avenue, Los Angeles, CA 90033, USA.
Metabolic rate and parameters associated with oxidative stress were
compared in two strains of mice, one of which, C57BL/6, exhibits an
extension of life span in response to caloric restriction while the
other, DBA/2, shows no such effect. Metabolic rate was higher in the
DBA/2 than in the C57BL/6 mice, when measured at 5-6months of age as
in vivo and in vitro rates of oxygen consumption or body temperature.
There were no remarkable inter-strain differences in activities of the
antioxidant enzymes, superoxide dismutase, catalase, and glutathione
peroxidase or in the rates of mitochondrial superoxide anion radical
generation in heart or skeletal muscles. Comparison of glutathione
redox state in the heart and skeletal muscles at 3 and 20months of age
indicated that the amount of glutathione (GSH) and the GSH:GSSG
(glutathione disulfide) ratio were relatively higher in the young DBA/
2 mice, but there were no inter-strain differences in the older mice.
The age-related elevation in the level of oxidative stress reflected
by GSH:GSSG ratio was greater in the C57BL/6 than DBA/2 mice. The
energy balance, indicated by the gain/loss in body weight per unit of
food consumed, is higher in C57BL/6 than DBA/2 mice. It is
hypothesized that the genotype-specific extension of life span by
caloric restriction may involve modulation of oxidative stress
produced as a result of an interplay between metabolic rate and energy
balance during aging.
PMID: 18541398 [PubMed - as supplied by publisher] |
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