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Science Forum Index » Anthropology - Paleo Forum » Paper: Inferring Human Colonization History Using a...
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| Robert Karl Stonjek... |
 Posted: Sat May 24, 2008 12:24 am |
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Inferring Human Colonization History Using a Copying Model
Garrett Hellenthal1, Adam Auton1,2, Daniel Falush1,3
1 Department of Statistics, University of Oxford, Oxford, United Kingdom
2 Department of Biological Statistics and Computational Biology, Cornell University, Ithaca, New York, United States of America
3 Department of Microbiology, Environmental Research Institute, Cork, Ireland
Abstract
Genome-wide scans of genetic variation can potentially provide detailed information on how modern humans colonized the world but require new methods of analysis. We introduce a statistical approach that uses Single Nucleotide Polymorphism (SNP) data to identify sharing of chromosomal segments between populations and uses the pattern of sharing to reconstruct a detailed colonization scenario. We apply our model to the SNP data for the 53 populations of the Human Genome Diversity Project described in Conrad et al. (Nature Genetics 38,1251-60, 2006). Our results are consistent with the consensus view of a single "Out-of-Africa" bottleneck and serial dilution of diversity during global colonization, including a prominent East Asian bottleneck. They also suggest novel details including: (1) the most northerly East Asian population in the sample (Yakut) has received a significant genetic contribution from the ancestors of the most northerly European one (Orcadian). (2) Native South Americans have received ancestry from a source closely related to modern North-East Asians (Mongolians and Oroquen) that is distinct from the sources for native North Americans, implying multiple waves of migration into the Americas. A detailed depiction of the peopling of the world is available in animated form.
Source: PLoS One [Open Access]
http://www.plosgenetics.org/article/info:doi/10.1371/journal.pgen.1000078
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