| |
 |
|
|
Science Forum Index » Life Extension Forum » Serum Dehydroepiandrosterone Sulfate Levels Predict...
Page 1 of 1
|
| Author |
Message |
| ... |
 Posted: Wed May 14, 2008 12:12 pm |
|
|
|
Guest
|
J Am Geriatr Soc. 2008 Apr 18 [Epub ahead of print] Links
Serum Dehydroepiandrosterone Sulfate Levels Predict Longevity in Men:
27-Year Follow-Up Study in a Community-Based Cohort (Tanushimaru
Study).Enomoto M, Adachi H, Fukami A, Furuki K, Satoh A, Otsuka M,
Kumagae SI, Nanjo Y, Shigetoh Y, Imaizumi T.
Department of Internal Medicine, Division of Cardiovascular Medicine,
Kurume University School of Medicine, Kurume, Japan.
OBJECTIVES: To determine whether serum dehydroepiandrosterone sulfate
(DHEAS) levels could predict longevity in residents. DESIGN:
Prospective community-based cohort study. SETTING: Community.
PARTICIPANTS: Nine hundred forty subjects (396 men, 544 women; aged 21
to 8 underwent a health examination in 1978. Serum DHEAS levels were
measured according to radioimmunoassay at baseline in all subjects,
and subjects were followed periodically until 2005. RESULTS: Baseline
DHEAS levels were higher in men than in women and decreased with age
in both sexes. In a Cox proportional hazards model, age, DHEAS
(inversely), blood pressure, and fasting plasma glucose were
significantly associated with shorter longevity in men but not in
women. Of these variables, high DHEAS levels in men were the strongest
predictor of longevity (beta=-2.032, hazard ratio=0.131, 95%
confidence interval=0.029-0.584 in the Cox proportional hazards model
after adjustment for age). The Kaplan-Meier survival curve, stratified
according to tertiles of DHEAS levels, in men after adjustments for
age, systolic blood pressure, and fasting plasma glucose showed
significantly (log-rank stat =10.6; P<.001) greater longevity in the
highest group (200 mug/dL) than in the moderate (130-199 mug/dL) or
lowest groups (129 mug/dL). CONCLUSION: This 27-year study in a
community-based cohort indicated that DHEAS level may be a predictor
of longevity in men, independent of age, blood pressure, and plasma
glucose.
PMID: 18422949 [PubMed - as supplied by publisher] |
|
|
| Back to top |
|
| |
|
Page 1 of 1
All times are GMT - 5 Hours
The time now is Sun Jul 06, 2008 8:17 pm
|
|
