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Science Forum Index » Life Extension Forum » The naked mole-rat: a new long-living model for human...
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 Posted: Wed May 14, 2008 12:09 pm |
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J Gerontol A Biol Sci Med Sci. 2005 Nov;60(11):1369-77. Links
The naked mole-rat: a new long-living model for human aging
research.Buffenstein R.
Department of Biology, City College of CUNY, Convent Ave. at 138th
St., New York, NY 10031, USA. rbuffen at (no spam) sci.ccny.cuny.edu
Tremendous variation in maximum life span among species overshadows
modest increases in longevity resulting from experimental
manipulation. Few aging studies focus on long-lived mammals even
though these species may expose mechanisms involved in resisting
aging. Naked mole-rats (NMRs approximately 35 grams) are the longest-
living (>28.3 years) rodents known. This review describes their
biology and potential use in aging research. Lifestyle features concur
with most evolutionary theories with the exception of the disposable
soma theory. Indeed, maximum life span is similar in breeders and
nonbreeders, and these highly fecund animals reproduce until they die.
Shared characteristics with calorie-restricted, methionine-restricted,
and dwarf mice models of extended longevity include reduced body
temperature; reduced thyroid, and blood glucose concentrations; and
low glycated hemoglobin; in addition to reduced incidence of cancer.
Young naked mole-rats surprisingly have high levels of accrued
oxidative damage. With their similar longevity quotient to humans,
these rodents may provide a novel opportunity to examine mechanisms
modulating aging.
PMID: 16339321 [PubMed - indexed for MEDLINE] |
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| Posted: Wed May 14, 2008 12:10 pm |
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Science. 2006 Nov 3;314(5800):825-8. Links
Comment in:
Science. 2006 Nov 3;314(5800):773-4.
Transgenic mice with a reduced core body temperature have an increased
life span.Conti B, Sanchez-Alavez M, Winsky-Sommerer R, Morale MC,
Lucero J, Brownell S, Fabre V, Huitron-Resendiz S, Henriksen S,
Zorrilla EP, de Lecea L, Bartfai T.
Harold L. Dorris Neurological Research Center, Scripps Research
Institute, La Jolla, CA 92037, USA. bconti at (no spam) scripps.edu
Reduction of core body temperature has been proposed to contribute to
the increased life span and the antiaging effects conferred by calorie
restriction (CR). Validation of this hypothesis has been difficult in
homeotherms, primarily due to a lack of experimental models. We report
that transgenic mice engineered to overexpress the uncoupling protein
2 in hypocretin neurons (Hcrt-UCP2) have elevated hypothalamic
temperature. The effects of local temperature elevation on the central
thermostat resulted in a 0.3 degrees to 0.5 degrees C reduction of the
core body temperature. Fed ad libitum, Hcrt-UCP2 transgenic mice had
the same caloric intake as their wild-type littermates but had
increased energy efficiency and a greater median life span (12%
increase in males; 20% increase in females). Thus, modest, sustained
reduction of core body temperature prolonged life span independent of
altered diet or CR.
PMID: 17082459 [PubMed - indexed for MEDLINE] |
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