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Science Forum Index » Life Extension Forum » A diet rich in conjugated linoleic acid and butter...
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| rs1000b at (no spam) yahoo.com... |
 Posted: Sun May 11, 2008 12:35 pm |
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J Nutr. 2008 Mar;138(3):509-14.
A diet rich in conjugated linoleic acid and butter increases lipid
peroxidation but does not affect atherosclerotic, inflammatory, or
diabetic risk markers in healthy young men.
Raff M, Tholstrup T, Basu S, Nonboe P, Sørensen MT, Straarup EM.
Department of Human Nutrition, Faculty of Life Sciences, University of
Copenhagen, Copenhagen, Denmark. mrf at (no spam) at (no spam) at (no spam) life.ku.dk
Intake of conjugated linoleic acid (CLA) has been demonstrated to
beneficially affect risk markers of atherosclerosis and diabetes in
rats. CLA is naturally found in milk fat, especially from cows fed a
diet high in oleic acid, and increased CLA intake can occur
concomitantly with increased milk fat intake. Our objective was to
investigate the effect of CLA as part of a diet rich in butter as a
source of milk fat on risk markers of atherosclerosis, inflammation,
diabetes type II, and lipid peroxidation. A total of 38 healthy young
men were given a diet with 115 g/d of CLA-rich fat (5.5 g/d CLA oil, a
mixture of 39.4% cis9, trans11 and 38.5% trans10, cis12) or of control
fat with a low content of CLA in a 5-wk double-blind, randomized,
parallel intervention study. We collected blood and urine before and
after the intervention. The fatty acid composition of plasma
triacylglycerol, cholesterol esters, and phospholipids reflected that
of the intervention diets. The CLA diet resulted in increased lipid
peroxidation measured as an 83% higher 8-iso-prostaglandin F2alpha
concentration compared with the control, P < 0.0001. We observed no
other significant differences in the effect of the interventions
diets. In conclusion, when given as part of a diet rich in butter, a
mixture of CLA isomers increased lipid peroxidation but did not affect
risk markers of cardiovascular disease, inflammation, or fasting
insulin and glucose concentrations.
PMID: 18287358 [PubMed - indexed for MEDLINE] |
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