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Science Forum Index » Life Extension Forum » A commercial extract of fruits and vegetables,...
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| rs1000b at (no spam) yahoo.com... |
 Posted: Sun May 11, 2008 12:17 pm |
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J Agric Food Chem. 2007 May 16;55(10):4258-63. Epub 2007 Apr 20.
A commercial extract of fruits and vegetables, Oxxynea, acts as a
powerful antiatherosclerotic supplement in an animal model by reducing
cholesterolemia, oxidative stress, and NADPH oxidase expression.
Sutra T, Décordé K, Riss J, Dallas C, Cristol JP, Rouanet JM.
EA 3762 Nutrition & Aliments, Place E. Bataillon, Université
Montpellier 2, 34095 Montpellier, France.
The effects of fruit and vegetable extract (Oxxynea) on plasma
cholesterol, early atherosclerosis, cardiac production of superoxide
anion, and NAD(P)H oxidase expression were studied in an animal model
of atherosclerosis. Thirty six hamsters were divided into two groups
of 18 and fed an atherogenic diet for 12 weeks. They received by
gavage either water or Oxxynea in water at a human dose equivalent of
10 fruits and vegetables per day. Oxxynea lowered plasma cholesterol
and non-HDL cholesterol, but not HDL-cholesterol, and increased plasma
antioxidant capacity. It also strongly reduced the area of aortic
fatty streak deposition by 77%, cardiac production of superoxide anion
by 45%, and p22phox subunit of NAD(P)H oxidase expression by 59%.
These findings support the view that chronic consumption of
antioxidants supplied by fruits and vegetables has potential
beneficial effects with respect to the development of atherosclerosis.
The underlying mechanism is related mainly to inhibiting pro-oxidant
factors and improving the serum lipid profile.
PMID: 17444653 [PubMed - indexed for MEDLINE] |
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