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Science Forum Index » Life Extension Forum » Beneficial effects of subcutaneous fat transplantation...
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| Olafur Pall Olafsson... |
 Posted: Fri May 09, 2008 3:42 pm |
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This study suggests it is the phyciology of visceral fat not it's
location that makes it so harmful.
Cell Metab. 2008 May;7(5):410-20.Related Articles
Beneficial effects of subcutaneous fat transplantation on metabolism.
Tran TT, Yamamoto Y, Gesta S, Kahn CR.
Joslin Diabetes Center and Harvard Medical School, Boston, MA 02215,
USA.
Subcutaneous (SC) and visceral (VIS) obesity are associated with
different risks of diabetes and the metabolic syndrome. To elucidate
whether these differences are due to anatomic location or intrinsic
differences in adipose depots, we characterized mice after
transplantation of SC or VIS fat from donor mice into either SC or VIS
regions of recipient mice. The group with SC fat transplanted into the
VIS cavity exhibited decreased body weight, total fat mass, and
glucose and insulin levels. These mice also exhibited improved insulin
sensitivity during hyperinsulinemic-euglycemic clamps with increased
whole-body glucose uptake, glucose uptake into endogenous fat, and
insulin suppression of hepatic glucose production. These effects were
observed to a lesser extent with SC fat transplanted to the SC area,
whereas VIS fat transplanted to the VIS area was without effect. These
data suggest that SC fat is intrinsically different from VIS fat and
produces substances that can act systemically to improve glucose
metabolism.
PMID: 18460332 [PubMed - in process]
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perfusion in subcutaneous and visceral adipose tissue during insulin
stimulation in nonobese and obese humans. [J Clin Endocrinol Metab.
2002] What are the physical characteristics associated with a normal
metabolic profile despite a high level of obesity in postmenopausal
women? [J Clin Endocrinol Metab. 2001] Improved glucose tolerance in
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[Diabetologia. 2007] » See all Related Articles... |
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