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Science Forum Index » Life Extension Forum » Drosophila germ-line modulation of insulin signaling...
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 Posted: Fri May 09, 2008 2:07 pm |
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Proc Natl Acad Sci U S A. 2008 Apr 29;105(17):6368-73. Epub 2008 Apr
23. Links
Drosophila germ-line modulation of insulin signaling and
lifespan.Flatt T, Min KJ, D'Alterio C, Villa-Cuesta E, Cumbers J,
Lehmann R, Jones DL, Tatar M.
Division of Biology and Medicine, Department of Ecology and
Evolutionary Biology, Brown University, Box G-W, Providence, RI 02912,
USA.
Ablation of germ-line precursor cells in Caenorhabditis elegans
extends lifespan by activating DAF-16, a forkhead transcription factor
(FOXO) repressed by insulin/insulin-like growth factor (IGF) signaling
(IIS). Signals from the gonad might thus regulate whole-organism aging
by modulating IIS. To date, the details of this systemic regulation of
aging by the reproductive system are not understood, and it is unknown
whether such effects are evolutionarily conserved. Here we report that
eliminating germ cells (GCs) in Drosophila melanogaster increases
lifespan and modulates insulin signaling. Long-lived germ-line-less
flies show increased production of Drosophila insulin-like peptides
(dilps) and hypoglycemia but simultaneously exhibit several
characteristics of IIS impedance, as indicated by up-regulation of the
Drosophila FOXO (dFOXO) target genes 4E-BP and l (2)efl and the
insulin/IGF-binding protein IMP-L2. These results suggest that signals
from the gonad regulate lifespan and modulate insulin sensitivity in
the fly and that the gonadal regulation of aging is evolutionarily
conserved.
PMID: 18434551 [PubMed - in process] |
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